The MG-QOL15 Japanese version: Validation and associations with clinical factors

Masayuki masuda, Kimiaki Utsugisawa, Shigeaki Suzuki, Yuriko Nagane, Chiaki Kabasawa, Yasushi Suzuki, Yuko Shimizu, Hiroya Utsumi, Kazuo Fujihara, Shinichiro Uchiyama, Norihiro Suzuki

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)


Introduction:: Our study aim was to produce a Japanese translation of the 15-item Myasthenia Gravis Quality-of-Life Scale (MG-QOL15), assess its reliability and validity, and examine clinical factors affecting self-perceived QOL in MG. Methods:: We evaluated 327 consecutive patients with MG seen at six neurological centers. All patients completed the Japanese version of the MG-QOL15 (MG-QOL15-J), the Beck Depression Inventory-second edition (BDI-II), and a generic health-related QOL questionnaire, the SF-36. Disease severity was determined according to the Myasthenia Gravis Foundation of America (MGFA) quantitative MG score and the MG composite. Results:: The MG-QOL15-J exhibited adequate internal reliability, test-retest repeatability, and concurrent validity with SF-36, disease severity, and known-patient groups categorized by MGFA post-intervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI-II as independent factors negatively affecting QOL. Conclusion:: The MG-QOL15-J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG.

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalMuscle and Nerve
Issue number2
Publication statusPublished - 2012 Aug


  • Cross-sectional study
  • Health-related quality of life
  • Myasthenia gravis
  • Questionnaire
  • Validity

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


Dive into the research topics of 'The MG-QOL15 Japanese version: Validation and associations with clinical factors'. Together they form a unique fingerprint.

Cite this