The microbiome in infectious disease and inflammation

Kenya Honda, Dan R. Littman

Research output: Contribution to journalReview articlepeer-review

593 Citations (Scopus)


The mammalian alimentary tract harbors hundreds of species of commensal microorganisms (microbiota) that intimately interact with the host and provide it with genetic, metabolic, and immunological attributes. Recent reports have indicated that the microbiota composition and its collective genomes (microbiome) are major factors in predetermining the type and robustness of mucosal immune responses. In this review, we discuss the recent advances in our understanding of host-microbiota interactions and their effect on the health and disease susceptibility of the host.

Original languageEnglish
Pages (from-to)759-795
Number of pages37
JournalAnnual Review of Immunology
Publication statusPublished - 2012 Apr
Externally publishedYes


  • Clostridium
  • Innate lymphoid cells
  • Intestinal microbiota
  • Segmented filamentous bacteria
  • Th17 cells
  • Treg cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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