Abstract
The mammalian alimentary tract harbors hundreds of species of commensal microorganisms (microbiota) that intimately interact with the host and provide it with genetic, metabolic, and immunological attributes. Recent reports have indicated that the microbiota composition and its collective genomes (microbiome) are major factors in predetermining the type and robustness of mucosal immune responses. In this review, we discuss the recent advances in our understanding of host-microbiota interactions and their effect on the health and disease susceptibility of the host.
| Original language | English |
|---|---|
| Pages (from-to) | 759-795 |
| Number of pages | 37 |
| Journal | Annual Review of Immunology |
| Volume | 30 |
| DOIs | |
| Publication status | Published - 2012 Apr |
| Externally published | Yes |
Keywords
- Clostridium
- Innate lymphoid cells
- Intestinal microbiota
- Segmented filamentous bacteria
- Th17 cells
- Treg cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
