The mitochondrial-derived peptide MOTS-c: A player in exceptional longevity?

Noriyuki Fuku; Helios Pareja-Galeano; Hirofumi Zempo; Rafael Alis; Yasumichi Arai; Alejandro Lucia; Nobuyoshi Hirose

doi:10.1111/acel.12389

The mitochondrial-derived peptide MOTS-c: A player in exceptional longevity?

Noriyuki Fuku, Helios Pareja-Galeano, Hirofumi Zempo, Rafael Alis, Yasumichi Arai, Alejandro Lucia, Nobuyoshi Hirose

Faculty of Nursing and Medical Care

Research output: Contribution to journal › Comment/debate › peer-review

70 Citations (Scopus)

Abstract

Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.

Original language	English
Pages (from-to)	921-923
Number of pages	3
Journal	Aging Cell
Volume	14
Issue number	6
DOIs	https://doi.org/10.1111/acel.12389
Publication status	Published - 2015 Dec 1

Keywords

Aging
Centenarians
Longevity gene
Longevity regulation
Mitochondria
Mitochondrial DNA
Mitochondrial DNA abnormalities
Molecular biology of aging

ASJC Scopus subject areas

Ageing
Cell Biology

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10.1111/acel.12389

Cite this

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title = "The mitochondrial-derived peptide MOTS-c: A player in exceptional longevity?",

abstract = "Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.",

keywords = "Aging, Centenarians, Longevity gene, Longevity regulation, Mitochondria, Mitochondrial DNA, Mitochondrial DNA abnormalities, Molecular biology of aging",

author = "Noriyuki Fuku and Helios Pareja-Galeano and Hirofumi Zempo and Rafael Alis and Yasumichi Arai and Alejandro Lucia and Nobuyoshi Hirose",

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T2 - A player in exceptional longevity?

AU - Fuku, Noriyuki

AU - Pareja-Galeano, Helios

AU - Zempo, Hirofumi

AU - Alis, Rafael

AU - Arai, Yasumichi

AU - Lucia, Alejandro

AU - Hirose, Nobuyoshi

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.

AB - Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.

KW - Aging

KW - Centenarians

KW - Longevity gene

KW - Longevity regulation

KW - Mitochondria

KW - Mitochondrial DNA

KW - Mitochondrial DNA abnormalities

KW - Molecular biology of aging

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JO - Aging Cell

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The mitochondrial-derived peptide MOTS-c: A player in exceptional longevity?

Abstract

Keywords

ASJC Scopus subject areas

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