The mitochondrial-derived peptide MOTS-c: A player in exceptional longevity?

Noriyuki Fuku, Helios Pareja-Galeano, Hirofumi Zempo, Rafael Alis, Yasumichi Arai, Alejandro Lucia, Nobuyoshi Hirose

Research output: Contribution to journalComment/debatepeer-review

70 Citations (Scopus)


Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.

Original languageEnglish
Pages (from-to)921-923
Number of pages3
JournalAging Cell
Issue number6
Publication statusPublished - 2015 Dec 1


  • Aging
  • Centenarians
  • Longevity gene
  • Longevity regulation
  • Mitochondria
  • Mitochondrial DNA
  • Mitochondrial DNA abnormalities
  • Molecular biology of aging

ASJC Scopus subject areas

  • Ageing
  • Cell Biology


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