@inproceedings{73d2651835564931b6cbd3268879872d,
title = "The NPe6 fluorescence measurements by using a fluorescence sensing system for skin photosensitivity risk assessment after photodynamic therapy",
abstract = "Background: Skin photosensitivity is a major side effect of photodynamic therapy (PDT). It is induced by the photosensitizer remaining in the skin. It is usually rapidly metabolized by the liver, but the pharmacokinetic profile varies widely among individuals. This makes it difficult to predict the incidence of skin photosensitivity. Therefore, we conducted a prospective study to investigate whether the NPe6 fluorescence intensity in skin after NPe6-PDT could be measured safely in human patients using a fluorescence sensing system for judging the risk of skin photosensitivity. Methods: The NPe6 fluorescence measurements using a constructed fluorescence sensing system at the inside of the arm were acquired prior to and 5 and 10 minutes after NPe6 administration as well as at the time of PDT (4-5 hours after administration), at discharge (2 or 3 days after PDT), and at 1 or 2 weeks after PDT. Participants were interviewed as to whether they had any complications at 2 weeks after PDT. Results: Nine male patients and one female patient entered this study. All of the measurements of NPe6 fluorescence in the skin could be obtained without any complications. The spectral peak was detected at the time of discharge (2-3 days after administration) in most cases and it decreased at 1 or 2 weeks after PDT. Conclusions: The fluorescence of NPe6 in the skin could be detected feasibly using the fluorescence sensing system in human patients. Measuring fluorescence intensity in the skin might be useful to predict the incidence of skin photosensitivity after PDT.",
keywords = "NPe6, Photodynamic therapy, lung cancer, skin photosensitivity",
author = "Keishi Ohtani and Jitsu Usuda and Emiyu Ogawa and Sachio Maehara and Kentaro Imai and Tatsuya Inoue and Masaru Hagiwara and Masatoshi Kakihana and Naohiro Kajiwara and Tatsuo Ohira and Tsunenori Arai and Norihiko Ikeda",
note = "Funding Information: This work was supported in part by the Adaptable and Seamless Technology Transfer Program (#AS2415004P) of the Japan Science and Technology Agency and Japan Agency for Medical Research and Development. The authors wish to acknowledge Ms. Marika Doi, Ms. Risa Hamada, and Ms. Reina Otsuki, graduate students of Keio University, for help in data analysis in this study. The authors are grateful to the medical editors from the Department of International Medical Communications of Tokyo Medical University for editing and reviewing the initial English manuscript. Publisher Copyright: {\textcopyright} 2018 SPIE.; Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII 2018 ; Conference date: 27-01-2018 Through 29-01-2018",
year = "2018",
doi = "10.1117/12.2287677",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Tayyaba Hasan and Kessel, {David H.}",
booktitle = "Optical Methods for Tumor Treatment and Detection",
}
