The ocular surface glycocalyx and its alteration in dry eye disease: A review

Yuichi Uchino

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Many studies have revealed that transmembrane mucins, large glycoproteins with heavily glycosylated glycans, are essential for maintaining ocular surface epithelium lubrication and wettability. Recent reports indicate that transmembrane mucins and galectin-3, a chimera type of galectin that binds b-galactoside in the glycan, play a crucial role in maintaining the epithelial glycocalyx barrier. This review summarizes current evidence regarding the role of galectin-3, the role of the three major transmembrane mucins (i.e., MUC1, MUC4, and MUC16), in the maintenance of ocular surface wettability and transcellular barrier. Pathological mechanisms of glycocalyx barrier disruption and epithelial surface wettability decreases in dry eye disease are also summarized. Lastly, new ophthalmic drugs that target transmembrane mucin are described.

Original languageEnglish
Pages (from-to)DES157-DES162
JournalInvestigative Ophthalmology and Visual Science
Issue number14 Special Issue
Publication statusPublished - 2018 Nov


  • Diquafosol
  • Galectin-3
  • Glycocalyx barrier
  • MUC1
  • MUC16
  • MUC4
  • Rebamipide
  • Transmembrane mucins

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'The ocular surface glycocalyx and its alteration in dry eye disease: A review'. Together they form a unique fingerprint.

Cite this