The recipient CXCL10 +1642C>G variation predicts survival outcomes after HLA fully matched unrelated bone marrow transplantation

Katsuya Nakata; Akiyoshi Takami; J. Luis Espinoza; Keitaro Matsuo; Yasuo Morishima; Makoto Onizuka; Takahiro Fukuda; Yoshihisa Kodera; Hideki Akiyama; Koichi Miyamura; Takehiko Mori; Shinji Nakao

doi:10.1016/j.clim.2012.11.009

The recipient CXCL10 +1642C>G variation predicts survival outcomes after HLA fully matched unrelated bone marrow transplantation

Katsuya Nakata, Akiyoshi Takami, J. Luis Espinoza, Keitaro Matsuo, Yasuo Morishima, Makoto Onizuka, Takahiro Fukuda, Yoshihisa Kodera, Hideki Akiyama, Koichi Miyamura, Takehiko Mori, Shinji Nakao

Department of Internal Medicine (Hematology)

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

CXCL10 is a chemoattractant for immune cells that is involved in several immune-inflammatory disorders. This study retrospectively examined the impact of a single nucleotide variation (rs3921, +. 1642C>G) in the CXCL10 gene on transplant outcomes in a cohort of 652 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. The recipient C/G or G/G genotype was found to be associated with a significantly better 5-year overall survival (OS) rate and a lower transplant-related mortality (TRM) rate than the recipient C/C genotype. The recipient C/G or G/G genotype also predicted a reduced incidence of death due to organ failure. The multivariate analysis showed the recipient C/G or G/G genotype to exhibit statistical trends toward beneficial effects on OS but not on TRM. CXCL10 genotyping could therefore be useful in predicting prognoses and creating therapeutic strategies for improving the final outcomes of patients who undergo allogeneic BMT.

Original language	English
Pages (from-to)	104-111
Number of pages	8
Journal	Clinical Immunology
Volume	146
Issue number	2
DOIs	https://doi.org/10.1016/j.clim.2012.11.009
Publication status	Published - 2013 Feb

Keywords

Bone marrow transplantation;
CXCL10;
Chemokine;
Organ failure
Single nucleotide variation;
Unrelated donor;

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.clim.2012.11.009

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Nakata, K., Takami, A., Espinoza, J. L., Matsuo, K., Morishima, Y., Onizuka, M., Fukuda, T., Kodera, Y., Akiyama, H., Miyamura, K., Mori, T., & Nakao, S. (2013). The recipient CXCL10 +1642C>G variation predicts survival outcomes after HLA fully matched unrelated bone marrow transplantation. Clinical Immunology, 146(2), 104-111. https://doi.org/10.1016/j.clim.2012.11.009

Nakata, K, Takami, A, Espinoza, JL, Matsuo, K, Morishima, Y, Onizuka, M, Fukuda, T, Kodera, Y, Akiyama, H, Miyamura, K, Mori, T & Nakao, S 2013, 'The recipient CXCL10 +1642C>G variation predicts survival outcomes after HLA fully matched unrelated bone marrow transplantation', Clinical Immunology, vol. 146, no. 2, pp. 104-111. https://doi.org/10.1016/j.clim.2012.11.009

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abstract = "CXCL10 is a chemoattractant for immune cells that is involved in several immune-inflammatory disorders. This study retrospectively examined the impact of a single nucleotide variation (rs3921, +. 1642C>G) in the CXCL10 gene on transplant outcomes in a cohort of 652 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. The recipient C/G or G/G genotype was found to be associated with a significantly better 5-year overall survival (OS) rate and a lower transplant-related mortality (TRM) rate than the recipient C/C genotype. The recipient C/G or G/G genotype also predicted a reduced incidence of death due to organ failure. The multivariate analysis showed the recipient C/G or G/G genotype to exhibit statistical trends toward beneficial effects on OS but not on TRM. CXCL10 genotyping could therefore be useful in predicting prognoses and creating therapeutic strategies for improving the final outcomes of patients who undergo allogeneic BMT.",

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author = "Katsuya Nakata and Akiyoshi Takami and Espinoza, {J. Luis} and Keitaro Matsuo and Yasuo Morishima and Makoto Onizuka and Takahiro Fukuda and Yoshihisa Kodera and Hideki Akiyama and Koichi Miyamura and Takehiko Mori and Shinji Nakao",

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AU - Nakata, Katsuya

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AU - Morishima, Yasuo

AU - Onizuka, Makoto

AU - Fukuda, Takahiro

AU - Kodera, Yoshihisa

AU - Akiyama, Hideki

AU - Miyamura, Koichi

AU - Mori, Takehiko

AU - Nakao, Shinji

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AB - CXCL10 is a chemoattractant for immune cells that is involved in several immune-inflammatory disorders. This study retrospectively examined the impact of a single nucleotide variation (rs3921, +. 1642C>G) in the CXCL10 gene on transplant outcomes in a cohort of 652 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. The recipient C/G or G/G genotype was found to be associated with a significantly better 5-year overall survival (OS) rate and a lower transplant-related mortality (TRM) rate than the recipient C/C genotype. The recipient C/G or G/G genotype also predicted a reduced incidence of death due to organ failure. The multivariate analysis showed the recipient C/G or G/G genotype to exhibit statistical trends toward beneficial effects on OS but not on TRM. CXCL10 genotyping could therefore be useful in predicting prognoses and creating therapeutic strategies for improving the final outcomes of patients who undergo allogeneic BMT.

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KW - CXCL10;

KW - Chemokine;

KW - Organ failure

KW - Single nucleotide variation;

KW - Unrelated donor;

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The recipient CXCL10 +1642C>G variation predicts survival outcomes after HLA fully matched unrelated bone marrow transplantation

Abstract

Keywords

ASJC Scopus subject areas

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