The risk of lymph node metastasis in T1 colorectal carcinoma

Seiichiro Yamamoto, Masahiko Watanabe, Hirotoshi Hasegawa, Hideo Baba, Kentaro Yoshinare, Junichi Shiraishi, Masaki Kitajima

Research output: Contribution to journalReview articlepeer-review

140 Citations (Scopus)


Background/Aims: The purpose of this study was to evaluate the risk of lymph node metastasis in patients with T1 colorectal carcinoma based on a uniform histopathology system, and to accomplish guidelines for additional surgery for endoscopically or locally removed T1 colorectal carcinoma. Methodology: A review was performed of 301 patients who underwent curative resection for T1 colorectal carcinoma between January 1970 and March 2001. The following clinicopathologic variables were evaluated using univariate and multivariate analysis: sex, age, location, size of tumor, macroscopic appearance, depth of submucosal invasion, lymphovascular invasion, and histologic grade. Lesions were subdivided according to the depth of submucosal invasion: sm1, submucosal invasion up to 500μm from the muscularis mucosa; sm2, submucosal invasion between 500 and 1000μm; sm3, submucosal invasion beyond 1000μm. Results: The overall lymph node metastasis rate was 6.3 per cent (19 of 301). Depth of submucosal invasion (sm3) and presence of lymphovascular invasion were significant risk factors for lymph node metastasis both univariately and multivariately. Conclusions: The findings of the current study demonstrated that significant risk factors for lymph node metastasis were level of submucosal invasion (sm3) and the presence of lymphovascular invasion. Surgery is indicated for patients with adverse factors.

Original languageEnglish
Pages (from-to)998-1000
Number of pages3
Issue number58
Publication statusPublished - 2004 Jul
Externally publishedYes


  • Colorectal T1 carcinoma
  • Lymph node metastasis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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