The role of matrix metalloproteinases in glioma invasion

Mitsutoshi Nakada, Yasunori Okada, Junkoh Yamashita

Research output: Contribution to journalReview articlepeer-review

70 Citations (Scopus)


The matrix metalloproteinase (MMP) family plays an important role in the degradation of extracellular matrix (ECM) in various physiological and pathological conditions. Accumulated evidence has suggested that MMPs contribute to cancer cell invasion of the surrounding normal tissues and metastasis through the cell-surface ECM degradation. Strong correlations have been reported between elevated MMP levels and tumor cell invasiveness in human gliomas. Among them, attention has been focused on gelatinases (MMP-2 and MMP-9) and membrane type MMPs (MT-MMPs). We discuss here the biological significance of these MMPs in the glioblastoma invasion processes. A better understanding of cell-ECM interactions will help in developing therapeutic strategies to decrease the invasion of gliomas.

Original languageEnglish
Pages (from-to)e262-e270
JournalFrontiers in Bioscience
Publication statusPublished - 2003
Externally publishedYes


  • Brain
  • Cancer
  • Glioma
  • Invasion
  • Matrix Metalloproteinase
  • Nervous system
  • Review
  • Tumor

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology


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