The role of pit-1 in the regulation of the rat growth hormone-releasing hormone receptor transcription by glucocorticoids

Haruo Nogami; Yoshiki Hiraoka; Kiyomoto Ogasawara; Sadakazu Aiso; Setsuji Hisano

doi:10.1677/jme.1.01870

The role of pit-1 in the regulation of the rat growth hormone-releasing hormone receptor transcription by glucocorticoids

Haruo Nogami, Yoshiki Hiraoka, Kiyomoto Ogasawara, Sadakazu Aiso, Setsuji Hisano

Department of Anatomy

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Glucocorticoids are involved in the regulation of the rat growth hormone-releasing hormone (GHRH) receptor gene expression, but they act only in the presence of the pituitary specific transcription factor, pit-1. In this study, the role of pit-1 in the glucocorticoid stimulation of the GHRH-receptor gene transcription was examined. The results suggest the presence of a silencer element in the promoter and it is postulated that pit-1 permits glucocorticoid action through suppressing the inhibitory effect of an as yet unknown factor that binds to this element. The present results also suggest that the synergistic activation of the rat GHRH-receptor gene transcription depends on the proper distance between the proximal glucocorticoid response element and the pit-1 binding site.

Original language	English
Pages (from-to)	477-488
Number of pages	12
Journal	Journal of Molecular Endocrinology
Volume	35
Issue number	3
DOIs	https://doi.org/10.1677/jme.1.01870
Publication status	Published - 2005 Dec

ASJC Scopus subject areas

Molecular Biology
Endocrinology

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abstract = "Glucocorticoids are involved in the regulation of the rat growth hormone-releasing hormone (GHRH) receptor gene expression, but they act only in the presence of the pituitary specific transcription factor, pit-1. In this study, the role of pit-1 in the glucocorticoid stimulation of the GHRH-receptor gene transcription was examined. The results suggest the presence of a silencer element in the promoter and it is postulated that pit-1 permits glucocorticoid action through suppressing the inhibitory effect of an as yet unknown factor that binds to this element. The present results also suggest that the synergistic activation of the rat GHRH-receptor gene transcription depends on the proper distance between the proximal glucocorticoid response element and the pit-1 binding site.",

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AU - Nogami, Haruo

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AU - Ogasawara, Kiyomoto

AU - Aiso, Sadakazu

AU - Hisano, Setsuji

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The role of pit-1 in the regulation of the rat growth hormone-releasing hormone receptor transcription by glucocorticoids

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