The sialyl-Tn antigen synthase genes regulates migration–proliferation dichotomy in prostate cancer cells under hypoxia

Daiki Yamamoto, Hiroshi Hongo, Takeo Kosaka, Natsumi Aoki, Mototsugu Oya, Toshinori Sato

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A low-oxygen (hypoxia) tumor microenvironment can facilitate chemotherapy and radiation therapy resistance in tumors and is associated with a poor prognosis. Hypoxia also affects PCa (prostate cancer) phenotype transformation and causes therapeutic resistance. Although O-glycans are known to be involved in the malignancy of various cancers under hypoxia, the expression and function of O-glycans in PCa are not well understood. In this study, the saccharide primer method was employed to analyze O-glycan expression in PCa cells. Results showed that the expression of sTn antigens was increased in PCa cells under hypoxia. Furthermore, it was found that ST6GalNAc1, the sTn antigen synthase gene, was involved in the migration–proliferation dichotomy and drug resistance in PCa cells under hypoxia. The results of this study will contribute to the development of novel diagnostic markers and drug targets for PCa under hypoxia.

Original languageEnglish
Pages (from-to)199-212
Number of pages14
JournalGlycoconjugate Journal
Volume40
Issue number2
DOIs
Publication statusPublished - 2023 Apr

Keywords

  • Hypoxia
  • LC-MS
  • Migration-proliferation dichotomy
  • O-glycan
  • Prostate cancer
  • Saccharide primer method

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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