The significance of antiphospholipid antibodies tests

Kotaro Otomo, Tatsuya Atsumi

Research output: Contribution to journalReview articlepeer-review


Antiphospholipid syndrome (APS) is an autoimmune disease defined by the presence of antiphospholipid antibodies (APL) in plasma of patients with thrombosis and/or pregnancy morbidity. In the classification criteria of APS, the presence of lupus anticoagulant (LA), anticardiolipin antibodies (aCL) or anti-β2-glycoprotein I antibodies (aβ2GPI) is necessary to diagnose APS. Recently, we defined "antiphospholipid score (aPL-S)" and evaluate the predictive value for thrombosis. In the study, aPL-S may be a predictive marker for developing thrombosis in patients with autoimmune diseases. In this article, we explain various APL assays for diagnosing APS in a clinical practice, introduce the study of "aPL-S", and discuss the significance of APL tests not only for a diagnosis of APS but also for a predictive marker of thrombosis in patients with autoimmune diseases.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalJapanese Journal of Clinical Immunology
Issue number2
Publication statusPublished - 2013
Externally publishedYes


  • Antiphospholipid antibody
  • Antiphospholipid score
  • Antiphospholipid syndrome
  • Sapporo criteria
  • Thrombosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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