TY - JOUR
T1 - The Significance of the Trp 64 Arg mutation of the β3-Adrenergic receptor gene in impaired glucose tolerance, non-isulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects
AU - Azuma, Nobuyuki
AU - Yoshimasa, Yasunao
AU - Nishimura, Haruo
AU - Yamamoto, Yuji
AU - Masuzaki, Hiroaki
AU - Suga, Junko
AU - Shigemoto, Michika
AU - Matsuoka, Naoki
AU - Tanaka, Tokuji
AU - Satoh, Noriko
AU - Igaki, Toshio
AU - Miyamoto, Yoshihiro
AU - Itoh, Hiroshi
AU - Yoshimasa, Takaaki
AU - Hosoda, Kiminori
AU - Nishi, Shigeo
AU - Nakao, Kazuwa
N1 - Funding Information:
From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan Submitted June 21, 1997; accepted September 3, 1997. Supported by grants for diabetes research from Otuka Pharmacential Co, Ltd, Tokushima, Japan, from the Smoking Research Foundation, and from The Investigation Committee on Abnormalities in Hormone Reception Mechanisms from the Ministry of Health and Welfare of Japan. Address reprint requests to Yasunao Yoshimasa, MD, PhD, Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606, Japan. Copyright © 1998 by WB. Saunders Company 0026-0495/98/4704-0016503.00/0
PY - 1998
Y1 - 1998
N2 - It has been reported that the trp 64 Arg mutation of the human β3- adrenergic receptor β3-AR) gene is related to an earlier age of onset of non-insulin-dependent diabetes mellitus (NIDDM) and features of insulin resistance and weight gain in morbidly obese patients. However, such findings have not been consistent in varying ethnic populations. In the present study, we investigated the frequency of the Trp 64 Arg mutation of the human Ab3- AR gene in Japanese control subject (n = 253) and in NIDDM (n = 314) and impaired glucose tolerance (IGT) patients (N = 100). We compared the frequency of the mutation with the body-mass index (BMI) in the these groups and with the metabolic clearance rate (MCR) of glucose in the NIDDM patients. A Trp 64 Arg mutation was observed in 36.7%, 31.6%, and 37.0% of the control, NIDDM, and IGT subject, respectively. The frequency of the homozygotes for the mutation was 4.3%, 4.8/5 and 3.0%, respectively. Neither the genotype frequency (Trp/Arg, Arg/Arg) nor the frequency of the mutated allele was significantly different among the three groups. The BMI of the subjects with the mutation was not significantly higher than that of the subjects without the mutation in each group. Furthermore, the allele frequency (A) was not different among the subjects with different BMIs (BMI < 22.0, 22.0 ≤ BMI ≤ 26.4, BMI > 26.4) in each group. In a separate group of NIDDM patients, the MCR of the subjects with intermediate BMIs (22.0 ≤ BMI ≤ 26.4) with the mutation tended to be lower than that of those without the mutation. In addition, the MCR of the subjects with the mutation in this group was significantly lower compared with that of those with a BMI less than 22. These results indicate that the Trp 64 Arg mutation of the β3-AR gene may not contribute to the development of NIDDM or be a determinant of obesity in the Japanese population. However, the mutation may contribute to insulin resistance in NIDDM patients with an intermediate BMI.
AB - It has been reported that the trp 64 Arg mutation of the human β3- adrenergic receptor β3-AR) gene is related to an earlier age of onset of non-insulin-dependent diabetes mellitus (NIDDM) and features of insulin resistance and weight gain in morbidly obese patients. However, such findings have not been consistent in varying ethnic populations. In the present study, we investigated the frequency of the Trp 64 Arg mutation of the human Ab3- AR gene in Japanese control subject (n = 253) and in NIDDM (n = 314) and impaired glucose tolerance (IGT) patients (N = 100). We compared the frequency of the mutation with the body-mass index (BMI) in the these groups and with the metabolic clearance rate (MCR) of glucose in the NIDDM patients. A Trp 64 Arg mutation was observed in 36.7%, 31.6%, and 37.0% of the control, NIDDM, and IGT subject, respectively. The frequency of the homozygotes for the mutation was 4.3%, 4.8/5 and 3.0%, respectively. Neither the genotype frequency (Trp/Arg, Arg/Arg) nor the frequency of the mutated allele was significantly different among the three groups. The BMI of the subjects with the mutation was not significantly higher than that of the subjects without the mutation in each group. Furthermore, the allele frequency (A) was not different among the subjects with different BMIs (BMI < 22.0, 22.0 ≤ BMI ≤ 26.4, BMI > 26.4) in each group. In a separate group of NIDDM patients, the MCR of the subjects with intermediate BMIs (22.0 ≤ BMI ≤ 26.4) with the mutation tended to be lower than that of those without the mutation. In addition, the MCR of the subjects with the mutation in this group was significantly lower compared with that of those with a BMI less than 22. These results indicate that the Trp 64 Arg mutation of the β3-AR gene may not contribute to the development of NIDDM or be a determinant of obesity in the Japanese population. However, the mutation may contribute to insulin resistance in NIDDM patients with an intermediate BMI.
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U2 - 10.1016/S0026-0495(98)90059-2
DO - 10.1016/S0026-0495(98)90059-2
M3 - Article
C2 - 9550545
AN - SCOPUS:0013689086
SN - 0026-0495
VL - 47
SP - 456
EP - 460
JO - Metabolism: clinical and experimental
JF - Metabolism: clinical and experimental
IS - 4
ER -
