The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner

Toshiyuki Nakagawa; Hideyuki Okano; Teiichi Furuichi; Jun Aruga; Katsuhiko Mikoshiba

doi:10.1073/pnas.88.14.6244

The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner

Toshiyuki Nakagawa, Hideyuki Okano, Teiichi Furuichi, Jun Aruga, Katsuhiko Mikoshiba

Research output: Contribution to journal › Article › peer-review

234 Citations (Scopus)

Abstract

Additional subtypes of the inositol 1,4,5-trisphosphate (InsP₃) receptor are expressed in a tissue-specific and developmentally specific manner. They differ from the InsP₃ receptor structure previously reported in two small variably spliced segments. One segment (SI) is located within the InsP₃ binding site, whereas another segment (SII) is located near putative sites for phosphorylation and ATP binding to modulate InsP₃ action on Ca²⁺ flux. Therefore, we speculate that selective use of InsP₃ receptor subtypes permits a tissue-specific and developmentally specific expression of functionally distinct channels.

Original language	English
Pages (from-to)	6244-6248
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	88
Issue number	14
DOIs	https://doi.org/10.1073/pnas.88.14.6244
Publication status	Published - 1991 Jul 15
Externally published	Yes

Keywords

Alternative splicing
Ligand-gated calcium channel

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The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner. / Nakagawa, Toshiyuki; Okano, Hideyuki; Furuichi, Teiichi et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, No. 14, 15.07.1991, p. 6244-6248.

Research output: Contribution to journal › Article › peer-review

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The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner

Abstract

Keywords

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