Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway.

Mamoru Watanabe; Motomi Yamazaki; Ryuichi Okamoto; Shinya Ohoka; Akihiro Araki; Tetsuya Nakamura; Takanori Kanai

doi:10.2174/1568010033484269

Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway.

Mamoru Watanabe, Motomi Yamazaki, Ryuichi Okamoto, Shinya Ohoka, Akihiro Araki, Tetsuya Nakamura, Takanori Kanai

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

Inflammatory bowel disease is thought to result from inappropriate activation of mucosal immune responses. Intestinal epithelial cells produce interleukin (IL)-7 that serves as a regulatory factor for IL-7 receptor (IL-7R)(+) mucosal lymphocytes. The pivotal role of mucosal IL-7/IL-7R dependent signals in the activation of mucosal immune responses that lead to the development of chronic intestinal inflammation are demonstrated. Therapeutic approaches targeting IL-7/IL-7R signal pathway may be feasible in the treatment of inflammatory bowel disease.

Original language	English
Pages (from-to)	119-123
Number of pages	5
Journal	Current drug targets. Inflammation and allergy
Volume	2
Issue number	2
DOIs	https://doi.org/10.2174/1568010033484269
Publication status	Published - 2003 Jun
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

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abstract = "Inflammatory bowel disease is thought to result from inappropriate activation of mucosal immune responses. Intestinal epithelial cells produce interleukin (IL)-7 that serves as a regulatory factor for IL-7 receptor (IL-7R)(+) mucosal lymphocytes. The pivotal role of mucosal IL-7/IL-7R dependent signals in the activation of mucosal immune responses that lead to the development of chronic intestinal inflammation are demonstrated. Therapeutic approaches targeting IL-7/IL-7R signal pathway may be feasible in the treatment of inflammatory bowel disease.",

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AU - Yamazaki, Motomi

AU - Okamoto, Ryuichi

AU - Ohoka, Shinya

AU - Araki, Akihiro

AU - Nakamura, Tetsuya

AU - Kanai, Takanori

PY - 2003/6

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AB - Inflammatory bowel disease is thought to result from inappropriate activation of mucosal immune responses. Intestinal epithelial cells produce interleukin (IL)-7 that serves as a regulatory factor for IL-7 receptor (IL-7R)(+) mucosal lymphocytes. The pivotal role of mucosal IL-7/IL-7R dependent signals in the activation of mucosal immune responses that lead to the development of chronic intestinal inflammation are demonstrated. Therapeutic approaches targeting IL-7/IL-7R signal pathway may be feasible in the treatment of inflammatory bowel disease.

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Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway.

Abstract

ASJC Scopus subject areas

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