@inbook{64f971f47a5a404ea249b8f6555088ff,
title = "Therapeutic implications of cortical spreading depression models in migraine",
abstract = "Migraine is among the most common and disabling neurological diseases in the world. Cortical spreading depression (CSD) is a wave of near-complete depolarization of neurons and glial cells that slowly propagates along the cortex creating the perception of aura. Evidence suggests that CSD can trigger migraine headache. Experimental models of CSD have been considered highly translational as they recapitulate migraine-related phenomena and have been validated for screening migraine therapeutics. Here we outline the essential components of validated experimental models of CSD and provide a comprehensive review of potential modulators and targets against CSD. We further focus on novel interventions that have been recently shown to suppress CSD susceptibility that may lead to therapeutic targets in migraine.",
keywords = "ASIC channel, Aura, Cortical spreading depolarization, Cortical spreading depression, Migraine, P2X7, Pannnexin-1, Susceptibility, TRP channels, Transcranial magnetic stimulation, Vagus nerve stimulation",
author = "Tsubasa Takizawa and Cenk Ayata and Chen, {Shih Pin}",
note = "Funding Information: This work was supported by was supported by JSPS KAKENHI (Grant number 19K16989 to T.T.), the Brain Research Center, National Yang-Ming University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan (to S.P.C.); the Ministry of Science and Technology, Taiwan [MOST-107-2314-B-010-021 & 108-2314-B-010-022-MY3 (to S.P.C.) & V108C-066 (to S.P.C.)]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",
year = "2020",
doi = "10.1016/bs.pbr.2020.05.009",
language = "English",
isbn = "9780128211083",
series = "Progress in Brain Research",
publisher = "Elsevier B.V.",
pages = "29--67",
editor = "Shuu-Jiun Wang and Shuu-Jiun Wang and Lau, {Chi Ieong} and Lau, {Chi Ieong} and Lau, {Chi Ieong} and Lau, {Chi Ieong} and Lau, {Chi Ieong}",
booktitle = "Update on Emerging Treatments for Migraine",
}