Therapeutic results for 100 patients with cancer of the mobile tongue treated with low dose rate interstitial irradiation

Yayoi Kobayashi; Katsuyuki Karasawa; Yoshiaki Komiya; Nahoko Hanyu; Masahiko Okamoto; Ta Chen Chang; Yurie Kiguchi; Ikuhiro Uchida; Shun'ichi Yoshida; Seiji Asoda

Therapeutic results for 100 patients with cancer of the mobile tongue treated with low dose rate interstitial irradiation

Yayoi Kobayashi, Katsuyuki Karasawa, Yoshiaki Komiya, Nahoko Hanyu, Masahiko Okamoto, Ta Chen Chang, Yurie Kiguchi, Ikuhiro Uchida, Shun'ichi Yoshida, Seiji Asoda

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Aim: To evaluate the conservativeness of low dose rate interstitial irradiation (LII) for cancer of the mobile tongue. Patients and Methods: Between 1975 and 2002, 100 consecutive patients (71 men, 29 women) underwent LII as curative treatment. Stages were I/II/III/IV= 16/63/16/4. Seventy-one cases were treated with LII alone and 29 cases treated combined with external irradiation. Median total dose of LII was 70 Gy 17 days. Results: Overall, 5- and 10-year local control and LII-treated patients' survival rates were 93% and 91%, 64% and 57%, respectively. Delayed neck metastases were observed in 21% of initially N0 cases, 56% of which could be salvaged by operation. Early stage and well-differentiated tumors carried better prognoses. Conclusion: LII of cancers of the mobile tongue results in good local control and survival. With careful monitoring of patients to ensure early detection of delayed metastases, LII should allow organ conservation and yield favourable therapeutic results compared with those of surgery.

Original language	English
Pages (from-to)	1689-1692
Number of pages	4
Journal	Anticancer research
Volume	27
Issue number	3 B
Publication status	Published - 2007 May
Externally published	Yes

Keywords

Cancer of mobile tongue
Interstitial irradiation
Low dose rate
Radiotherapy

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Therapeutic results for 100 patients with cancer of the mobile tongue treated with low dose rate interstitial irradiation",

abstract = "Aim: To evaluate the conservativeness of low dose rate interstitial irradiation (LII) for cancer of the mobile tongue. Patients and Methods: Between 1975 and 2002, 100 consecutive patients (71 men, 29 women) underwent LII as curative treatment. Stages were I/II/III/IV= 16/63/16/4. Seventy-one cases were treated with LII alone and 29 cases treated combined with external irradiation. Median total dose of LII was 70 Gy 17 days. Results: Overall, 5- and 10-year local control and LII-treated patients' survival rates were 93% and 91%, 64% and 57%, respectively. Delayed neck metastases were observed in 21% of initially N0 cases, 56% of which could be salvaged by operation. Early stage and well-differentiated tumors carried better prognoses. Conclusion: LII of cancers of the mobile tongue results in good local control and survival. With careful monitoring of patients to ensure early detection of delayed metastases, LII should allow organ conservation and yield favourable therapeutic results compared with those of surgery.",

keywords = "Cancer of mobile tongue, Interstitial irradiation, Low dose rate, Radiotherapy",

author = "Yayoi Kobayashi and Katsuyuki Karasawa and Yoshiaki Komiya and Nahoko Hanyu and Masahiko Okamoto and Chang, {Ta Chen} and Yurie Kiguchi and Ikuhiro Uchida and Shun'ichi Yoshida and Seiji Asoda",

year = "2007",

month = may,

language = "English",

volume = "27",

pages = "1689--1692",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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}

TY - JOUR

T1 - Therapeutic results for 100 patients with cancer of the mobile tongue treated with low dose rate interstitial irradiation

AU - Kobayashi, Yayoi

AU - Karasawa, Katsuyuki

AU - Komiya, Yoshiaki

AU - Hanyu, Nahoko

AU - Okamoto, Masahiko

AU - Chang, Ta Chen

AU - Kiguchi, Yurie

AU - Uchida, Ikuhiro

AU - Yoshida, Shun'ichi

AU - Asoda, Seiji

PY - 2007/5

Y1 - 2007/5

N2 - Aim: To evaluate the conservativeness of low dose rate interstitial irradiation (LII) for cancer of the mobile tongue. Patients and Methods: Between 1975 and 2002, 100 consecutive patients (71 men, 29 women) underwent LII as curative treatment. Stages were I/II/III/IV= 16/63/16/4. Seventy-one cases were treated with LII alone and 29 cases treated combined with external irradiation. Median total dose of LII was 70 Gy 17 days. Results: Overall, 5- and 10-year local control and LII-treated patients' survival rates were 93% and 91%, 64% and 57%, respectively. Delayed neck metastases were observed in 21% of initially N0 cases, 56% of which could be salvaged by operation. Early stage and well-differentiated tumors carried better prognoses. Conclusion: LII of cancers of the mobile tongue results in good local control and survival. With careful monitoring of patients to ensure early detection of delayed metastases, LII should allow organ conservation and yield favourable therapeutic results compared with those of surgery.

AB - Aim: To evaluate the conservativeness of low dose rate interstitial irradiation (LII) for cancer of the mobile tongue. Patients and Methods: Between 1975 and 2002, 100 consecutive patients (71 men, 29 women) underwent LII as curative treatment. Stages were I/II/III/IV= 16/63/16/4. Seventy-one cases were treated with LII alone and 29 cases treated combined with external irradiation. Median total dose of LII was 70 Gy 17 days. Results: Overall, 5- and 10-year local control and LII-treated patients' survival rates were 93% and 91%, 64% and 57%, respectively. Delayed neck metastases were observed in 21% of initially N0 cases, 56% of which could be salvaged by operation. Early stage and well-differentiated tumors carried better prognoses. Conclusion: LII of cancers of the mobile tongue results in good local control and survival. With careful monitoring of patients to ensure early detection of delayed metastases, LII should allow organ conservation and yield favourable therapeutic results compared with those of surgery.

KW - Cancer of mobile tongue

KW - Interstitial irradiation

KW - Low dose rate

KW - Radiotherapy

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M3 - Article

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AN - SCOPUS:34249339447

SN - 0250-7005

VL - 27

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JO - Anticancer research

JF - Anticancer research

IS - 3 B

ER -

Therapeutic results for 100 patients with cancer of the mobile tongue treated with low dose rate interstitial irradiation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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