Therapeutic strategies for implantation failure due to endometrial dysfunction

Tetsuo Maruyama

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Dramatic advances in assisted reproductive technologies have greatly improved the pregnancy rate for infertile couples. Recently, however, the recent pregnancy rates and live-birth rates have not significantly increased, mainly because there are very few effective treatments available for implantation failure and subsequent early pregnancy loss. Successful implantation requires good embryo quality, appropriately timed and arranged endometrial receptivity, and the efficient crosstalk between the embryo and the receptive endometrium. It is thought that impairment of any one of these factors or biological processes may result in implantation failure. In this review article, I have focused on endometrial dysfunction as a cause of implantation failure, and discuss its possible etiologies and therapeutic strategies.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalJournal of Mammalian Ova Research
Issue number3
Publication statusPublished - 2009 Oct 1


  • Endometrium
  • Human
  • IVF-ET
  • Implantation
  • Repeated failure

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology


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