Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants

Reina Wada; Takashi Kumon; Robert Kourist; Hiromichi Ohta; Daisuke Uemura; Shosuke Yoshida; Kenji Miyamoto

doi:10.1016/j.tetlet.2013.01.080

Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants

Reina Wada, Takashi Kumon, Robert Kourist, Hiromichi Ohta, Daisuke Uemura, Shosuke Yoshida, Kenji Miyamoto

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We have developed a thermally driven domino reaction for the synthesis of (S)-a-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids. Crown Copyright.

Original language	English
Pages (from-to)	1921-1923
Number of pages	3
Journal	Tetrahedron Letters
Volume	54
Issue number	15
DOIs	https://doi.org/10.1016/j.tetlet.2013.01.080
Publication status	Published - 2013 Apr 10

Keywords

A-Arylpropionates
Active site
Domino reaction
Thermal spontaneous decarboxylation
Thermostable esterase

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2013.01.080

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abstract = "We have developed a thermally driven domino reaction for the synthesis of (S)-a-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids. Crown Copyright.",

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T1 - Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants

AU - Wada, Reina

AU - Kumon, Takashi

AU - Kourist, Robert

AU - Ohta, Hiromichi

AU - Uemura, Daisuke

AU - Yoshida, Shosuke

AU - Miyamoto, Kenji

PY - 2013/4/10

Y1 - 2013/4/10

N2 - We have developed a thermally driven domino reaction for the synthesis of (S)-a-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids. Crown Copyright.

AB - We have developed a thermally driven domino reaction for the synthesis of (S)-a-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids. Crown Copyright.

KW - A-Arylpropionates

KW - Active site

KW - Domino reaction

KW - Thermal spontaneous decarboxylation

KW - Thermostable esterase

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JF - Tetrahedron Letters

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ER -

Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants

Abstract

Keywords

ASJC Scopus subject areas

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