Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan

Akiomi Inoue, Norito Kawakami, Masao Ishizaki, Masaji Tabata, Masao Tsuchiya, Miki Akiyama, Akiko Kitazume, Mitsuyo Kuroda, Akihito Shimazu

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Objective: Three job stress models/concepts (the job demands-control [DC] model, the effort-reward imbalance [ERI] model, and organizational justice) have been linked to coronary heart disease (CHD) at work. In recent years, oxidative DNA damage has been identified as a new risk factor for CHD. However, evidence for the association between these job stressors and oxidative DNA damage is limited. The present cross-sectional study investigated the association between these job stress models/concepts and oxidative DNA damage as a possible mediator of the adverse health effects of job stress. Methods: A total of 166 male and 51 female workers of a manufacturing factory in Japan were surveyed using a mailed questionnaire regarding job stressors and demographic, occupational, and lifestyle variables. Urinary concentrations of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, were also measured. Results: In male subjects, the urinary concentrations of 8-OHdG were significantly higher among the group with lower interactional justice, one of the two components of organizational justice; however, no association was observed with the DC model or the ERI model. In female subjects, high job demands/control ratio was significantly and positively associated with the urinary concentrations of 8-OHdG. Conclusion: Interactional justice among male workers and the DC model-based strain among female workers may be associated with increased urinary concentrations of 8-OHdG which possibly reflects oxidative DNA damage.

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalJournal of Psychosomatic Research
Issue number4
Publication statusPublished - 2009 Apr
Externally publishedYes


  • Coronary heart disease
  • Effort-reward imbalance model
  • Job demands-control model
  • Organizational justice
  • Urinary 8-OHdG

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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