Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata

Weifang Wang; Taiko Oda; Ayako Fujita; Remy E.P. Mangindaan; Takahiro Nakazawa; Kazuyo Ukai; Hisayoshi Kobayashi; Michio Namikoshi

doi:10.1016/j.tet.2006.10.060

Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata

Weifang Wang, Taiko Oda, Ayako Fujita, Remy E.P. Mangindaan, Takahiro Nakazawa, Kazuyo Ukai, Hisayoshi Kobayashi, Michio Namikoshi

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Three new sulfur-containing alkaloids, polycarpaurines A (1), B (2), and C (3) were isolated from the tropical ascidian Polycarpa aurata collected in Indonesia, together with six known compounds (4-9). The structures of new compounds were assigned on the basis of their spectral data. Compounds 1, 3, 4, and 8 inhibited colony formation of Chinese hamster V79 cells with EC₅₀ values of 6.8, 8.6, 3.8, and 10 μM, respectively. Compounds 2 and 7 showed modest activity against V79 cells (EC₅₀>10 μM).

Original language	English
Pages (from-to)	409-412
Number of pages	4
Journal	Tetrahedron
Volume	63
Issue number	2
DOIs	https://doi.org/10.1016/j.tet.2006.10.060
Publication status	Published - 2007 Jan 8
Externally published	Yes

Keywords

Ascidian
Polycarpa aurata
Polycarpaurine
Structure assignment
Sulfur-containing alkaloid

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2006.10.060

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title = "Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata",

abstract = "Three new sulfur-containing alkaloids, polycarpaurines A (1), B (2), and C (3) were isolated from the tropical ascidian Polycarpa aurata collected in Indonesia, together with six known compounds (4-9). The structures of new compounds were assigned on the basis of their spectral data. Compounds 1, 3, 4, and 8 inhibited colony formation of Chinese hamster V79 cells with EC50 values of 6.8, 8.6, 3.8, and 10 μM, respectively. Compounds 2 and 7 showed modest activity against V79 cells (EC50>10 μM).",

keywords = "Ascidian, Polycarpa aurata, Polycarpaurine, Structure assignment, Sulfur-containing alkaloid",

author = "Weifang Wang and Taiko Oda and Ayako Fujita and Mangindaan, {Remy E.P.} and Takahiro Nakazawa and Kazuyo Ukai and Hisayoshi Kobayashi and Michio Namikoshi",

note = "Funding Information: We thank Mr. H. Rotinsulu and Ms. D. Wewengkang for sample collection. This work was supported in part by a Grant-in-Aid for Scientific Research on Priority Areas 17035029 from The Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan to M.N.",

year = "2007",

month = jan,

day = "8",

doi = "10.1016/j.tet.2006.10.060",

language = "English",

volume = "63",

pages = "409--412",

journal = "Tetrahedron",

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TY - JOUR

T1 - Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata

AU - Wang, Weifang

AU - Oda, Taiko

AU - Fujita, Ayako

AU - Mangindaan, Remy E.P.

AU - Nakazawa, Takahiro

AU - Ukai, Kazuyo

AU - Kobayashi, Hisayoshi

AU - Namikoshi, Michio

N1 - Funding Information: We thank Mr. H. Rotinsulu and Ms. D. Wewengkang for sample collection. This work was supported in part by a Grant-in-Aid for Scientific Research on Priority Areas 17035029 from The Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan to M.N.

PY - 2007/1/8

Y1 - 2007/1/8

N2 - Three new sulfur-containing alkaloids, polycarpaurines A (1), B (2), and C (3) were isolated from the tropical ascidian Polycarpa aurata collected in Indonesia, together with six known compounds (4-9). The structures of new compounds were assigned on the basis of their spectral data. Compounds 1, 3, 4, and 8 inhibited colony formation of Chinese hamster V79 cells with EC50 values of 6.8, 8.6, 3.8, and 10 μM, respectively. Compounds 2 and 7 showed modest activity against V79 cells (EC50>10 μM).

AB - Three new sulfur-containing alkaloids, polycarpaurines A (1), B (2), and C (3) were isolated from the tropical ascidian Polycarpa aurata collected in Indonesia, together with six known compounds (4-9). The structures of new compounds were assigned on the basis of their spectral data. Compounds 1, 3, 4, and 8 inhibited colony formation of Chinese hamster V79 cells with EC50 values of 6.8, 8.6, 3.8, and 10 μM, respectively. Compounds 2 and 7 showed modest activity against V79 cells (EC50>10 μM).

KW - Ascidian

KW - Polycarpa aurata

KW - Polycarpaurine

KW - Structure assignment

KW - Sulfur-containing alkaloid

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DO - 10.1016/j.tet.2006.10.060

M3 - Article

AN - SCOPUS:33845225453

SN - 0040-4020

VL - 63

SP - 409

EP - 412

JO - Tetrahedron

JF - Tetrahedron

IS - 2

ER -

Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata

Abstract

Keywords

ASJC Scopus subject areas

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