Thymoma-associated T-cell immunodeficiency after radiotherapy: A case report

Kensuke Nakagawara; Shotaro Chubachi; Shuhei Azekawa; Shiro Otake; Ayaka Saito; Masahiko Okada; Ko Lee; Katsunori Masaki; Naoyoshi Koike; Hirofumi Kamata; Ichiro Kawada; Shigeaki Suzuki; Makoto Ishii; Koichi Fukunaga

doi:10.1016/j.rmcr.2021.101408

Thymoma-associated T-cell immunodeficiency after radiotherapy: A case report

Kensuke Nakagawara, Shotaro Chubachi, Shuhei Azekawa, Shiro Otake, Ayaka Saito, Masahiko Okada, Ko Lee, Katsunori Masaki, Naoyoshi Koike, Hirofumi Kamata, Ichiro Kawada, Shigeaki Suzuki, Makoto Ishii, Koichi Fukunaga

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Acquired immunodeficiency in thymoma (Good's syndrome) without hypogammaglobulinemia is a rare condition. Here we describe the case of a 29-year-old Japanese woman with thymoma-associated T cell immunodeficiency after radiation therapy. She was admitted to the hospital with refractory pneumonia, which resulted from as T cell immunodeficiency, as revealed through low peripheral lymphocytes and oral candidiasis triggered through radiotherapy and required long-term antimicrobial therapy. Although radiotherapy is commonly administered for thymoma, our findings suggest that physicians should consider carrying out lymphocyte counts during thymoma treatment.

Original language	English
Article number	101408
Journal	Respiratory Medicine Case Reports
Volume	33
DOIs	https://doi.org/10.1016/j.rmcr.2021.101408
Publication status	Published - 2021 Jan

Keywords

Myasthenia gravis
Oral candidiasis
Pneumoniae
Radiotherapy
T-cell immunodeficiency
Thymoma

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/j.rmcr.2021.101408

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title = "Thymoma-associated T-cell immunodeficiency after radiotherapy: A case report",

abstract = "Acquired immunodeficiency in thymoma (Good's syndrome) without hypogammaglobulinemia is a rare condition. Here we describe the case of a 29-year-old Japanese woman with thymoma-associated T cell immunodeficiency after radiation therapy. She was admitted to the hospital with refractory pneumonia, which resulted from as T cell immunodeficiency, as revealed through low peripheral lymphocytes and oral candidiasis triggered through radiotherapy and required long-term antimicrobial therapy. Although radiotherapy is commonly administered for thymoma, our findings suggest that physicians should consider carrying out lymphocyte counts during thymoma treatment.",

keywords = "Myasthenia gravis, Oral candidiasis, Pneumoniae, Radiotherapy, T-cell immunodeficiency, Thymoma",

author = "Kensuke Nakagawara and Shotaro Chubachi and Shuhei Azekawa and Shiro Otake and Ayaka Saito and Masahiko Okada and Ko Lee and Katsunori Masaki and Naoyoshi Koike and Hirofumi Kamata and Ichiro Kawada and Shigeaki Suzuki and Makoto Ishii and Koichi Fukunaga",

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doi = "10.1016/j.rmcr.2021.101408",

language = "English",

volume = "33",

journal = "Respiratory Medicine Case Reports",

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T1 - Thymoma-associated T-cell immunodeficiency after radiotherapy

T2 - A case report

AU - Nakagawara, Kensuke

AU - Chubachi, Shotaro

AU - Azekawa, Shuhei

AU - Otake, Shiro

AU - Saito, Ayaka

AU - Okada, Masahiko

AU - Lee, Ko

AU - Masaki, Katsunori

AU - Koike, Naoyoshi

AU - Kamata, Hirofumi

AU - Kawada, Ichiro

AU - Suzuki, Shigeaki

AU - Ishii, Makoto

AU - Fukunaga, Koichi

PY - 2021/1

Y1 - 2021/1

N2 - Acquired immunodeficiency in thymoma (Good's syndrome) without hypogammaglobulinemia is a rare condition. Here we describe the case of a 29-year-old Japanese woman with thymoma-associated T cell immunodeficiency after radiation therapy. She was admitted to the hospital with refractory pneumonia, which resulted from as T cell immunodeficiency, as revealed through low peripheral lymphocytes and oral candidiasis triggered through radiotherapy and required long-term antimicrobial therapy. Although radiotherapy is commonly administered for thymoma, our findings suggest that physicians should consider carrying out lymphocyte counts during thymoma treatment.

AB - Acquired immunodeficiency in thymoma (Good's syndrome) without hypogammaglobulinemia is a rare condition. Here we describe the case of a 29-year-old Japanese woman with thymoma-associated T cell immunodeficiency after radiation therapy. She was admitted to the hospital with refractory pneumonia, which resulted from as T cell immunodeficiency, as revealed through low peripheral lymphocytes and oral candidiasis triggered through radiotherapy and required long-term antimicrobial therapy. Although radiotherapy is commonly administered for thymoma, our findings suggest that physicians should consider carrying out lymphocyte counts during thymoma treatment.

KW - Myasthenia gravis

KW - Oral candidiasis

KW - Pneumoniae

KW - Radiotherapy

KW - T-cell immunodeficiency

KW - Thymoma

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DO - 10.1016/j.rmcr.2021.101408

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JO - Respiratory Medicine Case Reports

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ER -

Thymoma-associated T-cell immunodeficiency after radiotherapy: A case report

Abstract

Keywords

ASJC Scopus subject areas

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