Time-course of salivary metabolomic profiles during radiation therapy for head and neck cancer

Wakako Yatsuoka, Takao Ueno, Kanako Miyano, Ayame Enomoto, Sana Ota, Masahiro Sugimoto, Yasuhito Uezono

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Oral mucositis (OM) is one of the most frequently observed adverse oral events in radiation therapy for patients with head and neck cancer. Thus, objective evaluation of OM severity is needed for early and timely intervention. Here, we analyzed the time-course of salivary metabolomic profiles during the radiation therapy. The severity of OM (National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events v3.0) of nine patients with head and neck cancer was evaluated. Partial least squares regression-discriminant analysis, using samples collected before radiation therapy, showed that histidine and tyrosine highly discriminated high-grade OM from low-grade OM before the start of radiation therapy (significant difference, p = 0.048 for both metabolites). Further, the pretreatment concentrations of gamma-aminobutyric acid and 2-aminobutyric acids were higher in the high-grade OM group. Although further validations are still necessary, this study showed potentially associated metabolites with worse radiotherapy-related OM among patients with head and neck cancer.

Original languageEnglish
Article number2631
JournalJournal of Clinical Medicine
Volume10
Issue number12
DOIs
Publication statusPublished - 2021 Jun 2

Keywords

  • Capillary electrophoresis-mass spectrometry
  • Metabolomic analysis
  • Oral mucositis
  • Radiation therapy
  • Saliva

ASJC Scopus subject areas

  • General Medicine

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