Time-Series Analysis of Tumorigenesis in a Murine Skin Carcinogenesis Model

Yoshimasa Aoto, Kazuhiro Okumura, Tsuyoshi Hachiya, Sumitaka Hase, Yuichi Wakabayashi, Fuyuki Ishikawa, Yasubumi Sakakibara

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Recent years have witnessed substantial progress in understanding tumor heterogeneity and the process of tumor progression; however, the entire process of the transition of tumors from a benign to metastatic state remains poorly understood. In the present study, we performed a prospective cancer genome-sequencing analysis by employing an experimental carcinogenesis mouse model of squamous cell carcinoma to systematically understand the evolutionary process of tumors. We surgically collected a part of a lesion of each tumor and followed the progression of these tumors in vivo over time. Comparative time-series analysis of the genomes of tumors with different fates, i.e., those that eventually metastasized and regressed, suggested that these tumors acquired and inherited different mutations. These findings suggest that despite the occurrence of an intra-tumor selection event for malignant alteration during the transformation from early- to late-stage papilloma, the fate determination of tumors might be determined at an even earlier stage.

Original languageEnglish
Article number12994
JournalScientific reports
Issue number1
Publication statusPublished - 2018 Dec 1

ASJC Scopus subject areas

  • General


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