Toll-like receptor signaling and IRF transcription factors

Kenya Honda, Tadatsugu Taniguchi

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


Interferon regulatory factors (IRFs) were originally discovered in the context of type I interferon (IFN-α/β) gene induction, and subsequent studies on these transcription factors have revealed their remarkable functional diversity in regulating immune systems. Indeed, the critical involvement of IRF members in innate and adaptive immune responses has recently gained much attention, particularly with the recent discovery of Toll-like receptors (TLRs) and analyses of their critical functions in linking the innate and adaptive immune responses.

Original languageEnglish
Pages (from-to)290-295
Number of pages6
JournalIUBMB Life
Issue number5-6
Publication statusPublished - 2006 May
Externally publishedYes


  • Adaptive immune response
  • Innate immune response
  • Interferon regulatory factors
  • Toll-like receptors and signaling

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology


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