Topical naphazoline in the treatment of myasthenic blepharoptosis

Yuriko Nagane, Kimiaki Utsugisawa, Shigeaki Suzuki, Masayuki Masuda, Yuko Shimizu, Hiroya Utsumi, Shinichiro Uchiyama, Norihiro Suzuki

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Introduction. When treating ocular myasthenia gravis (MG), the risk/benefit profile of corticosteroids is unclear, and acetylcholinesterase inhibitors are not very effective. We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis. Methods. Sixty MG patients with blepharoptosis (32 with ocular symptoms only and 28 with mild generalized symptoms) were enrolled in a multicenter open trial of topical naphazoline. The effects were reported by patients via a questionnaire and were also confirmed for each patient at the clinic. Results. Among 70 eyes of 60 patients, 20 eyes (28.6%) of 17 patients (28.3%) exhibited a marked response (full eye opening), and 24 eyes (34.3%) of 20 patients (33.3%) showed a good response (adequate but incomplete eye opening). Topical naphazoline was evaluated as useful in the treatment of myasthenic blepharoptosis by >70% of the patients. Conclusions. Topical naphazoline was found to be an effective supplementary symptomatic treatment for myasthenic blepharoptosis.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalMuscle and Nerve
Issue number1
Publication statusPublished - 2011 Jul


  • Blepharoptosis
  • Eyewash
  • Myasthenia gravis
  • Naphazoline
  • Open trial

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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