Total synthesis and bioactivity of resolvin E2

Seiji Ogawa; Daisuke Urabe; Yoshiyuki Yokokura; Hiroyuki Arai; Makoto Arita; Masayuki Inoue

doi:10.1021/ol901350g

Total synthesis and bioactivity of resolvin E2

Seiji Ogawa, Daisuke Urabe, Yoshiyuki Yokokura, Hiroyuki Arai, Makoto Arita, Masayuki Inoue

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Image Presented Resolvin E2 is a potent anti-inflammatory compound, derived from eicosapentaenoic acid. The efficient total synthesis of resolvin E2 by taking advantage of its intrinsic pseudoenantiomeric substructures is reported. The synthetic resolvin E2 proved to be biologically active in blocking neutrophil infiltration and reducing proinflammatory cytokines in the acute peritonitis model.

Original language	English
Pages (from-to)	3602-3605
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	16
DOIs	https://doi.org/10.1021/ol901350g
Publication status	Published - 2009 Aug 20
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol901350g

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abstract = "Image Presented Resolvin E2 is a potent anti-inflammatory compound, derived from eicosapentaenoic acid. The efficient total synthesis of resolvin E2 by taking advantage of its intrinsic pseudoenantiomeric substructures is reported. The synthetic resolvin E2 proved to be biologically active in blocking neutrophil infiltration and reducing proinflammatory cytokines in the acute peritonitis model.",

author = "Seiji Ogawa and Daisuke Urabe and Yoshiyuki Yokokura and Hiroyuki Arai and Makoto Arita and Masayuki Inoue",

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AU - Ogawa, Seiji

AU - Urabe, Daisuke

AU - Yokokura, Yoshiyuki

AU - Arai, Hiroyuki

AU - Arita, Makoto

AU - Inoue, Masayuki

PY - 2009/8/20

Y1 - 2009/8/20

N2 - Image Presented Resolvin E2 is a potent anti-inflammatory compound, derived from eicosapentaenoic acid. The efficient total synthesis of resolvin E2 by taking advantage of its intrinsic pseudoenantiomeric substructures is reported. The synthetic resolvin E2 proved to be biologically active in blocking neutrophil infiltration and reducing proinflammatory cytokines in the acute peritonitis model.

AB - Image Presented Resolvin E2 is a potent anti-inflammatory compound, derived from eicosapentaenoic acid. The efficient total synthesis of resolvin E2 by taking advantage of its intrinsic pseudoenantiomeric substructures is reported. The synthetic resolvin E2 proved to be biologically active in blocking neutrophil infiltration and reducing proinflammatory cytokines in the acute peritonitis model.

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Total synthesis and bioactivity of resolvin E2

Abstract

ASJC Scopus subject areas

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