Total synthesis and biological evaluation of auripyrones A and B

Ichiro Hayakawa, Takuma Takemura, Emi Fukasawa, Yuta Ebihara, Natsuki Sato, Takayasu Nakamura, Kiyotake Suenaga, Hideo Kigoshi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The total synthesis of auripyrones was achieved by using a novel aldol-type reaction of γ-pyrone as a key step. From this synthetic work, we have established the stereostructure and absolute configuration of auripyrone B. Furthermore, the cytotoxicities of auripyrones against a panel of 39 human cancer cell lines (termed JFCR39) at the Japanese Foundation for Cancer Research were investigated. The patterns of the differential cytotoxicities of auripyrones were COMPARE negative, suggesting that they inhibit cancer cell proliferation through a novel mechanism.

Original languageEnglish
Pages (from-to)1077-1092
Number of pages16
JournalBulletin of the Chemical Society of Japan
Issue number10
Publication statusPublished - 2012

ASJC Scopus subject areas

  • General Chemistry


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