Total synthesis and stereochemical determination of yoshinone A

Seiichi Shinomiya, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


In 2014, the γ-pyrone-containing polyketide, yoshinone A, was isolated from the marine cyanobacterium Leptolyngbya sp. and its structure was determined. Yoshinone A inhibited differentiation of 3T3-L1 cells into adipocytes, with an EC50 value of 420 nM without any cytotoxicity, and therefore is expected to be a lead compound for obesity drugs. To establish its absolute configuration, and to provide sufficient amounts for further research, the total synthesis of yoshinone A was achieved through synthesis of its two possible diastereomers.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
Publication statusPublished - 2016 Dec 1


  • Leptolyngbya sp.
  • Marine cyanobacteria
  • Polyketide
  • Total synthesis
  • Yoshinone A

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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