Total Synthesis and Structural Revision of Clavilactone D

Ken Ichi Takao, Ryuichi Nemoto, Kento Mori, Ayumi Namba, Keisuke Yoshida, Akihiro Ogura

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


A structural revision of clavilactone D, a potent inhibitor of protein tyrosine kinases, was achieved by total syntheses of two newly proposed structures. The syntheses relied on ring-opening/ring-closing metathesis, which transformed a cyclobutenecarboxylate into a γ-butenolide. The syntheses confirmed that the correct structure of clavilactone D has an amino group at C-3 instead of a hydroxy group at C-2 in the originally proposed structure.

Original languageEnglish
Pages (from-to)3828-3831
Number of pages4
JournalChemistry - A European Journal
Issue number16
Publication statusPublished - 2017 Mar 17


  • medium-ring compounds
  • metathesis
  • natural products
  • structure elucidation
  • total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


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