Total synthesis of Antibiotic Нуgromycin A

Noritaka Chida, Masami Ohtsuka, Keiichi Nakazawa, Seiichiro Ogawa

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)


The first total synthesis of the antibiotic (−)-hygromycin A (1) has been achieved by a coupling reaction of the sugar moiety (2) and the cyclitol moiety (3). Both components were synthesized in homochiral forms starting from D-glucose. This synthesis fully confirmed the unique structure of 1, which is much different from other usual aminocyclitol antibiotics.

Original languageEnglish
Pages (from-to)2976-2983
Number of pages8
JournalJournal of Organic Chemistry
Issue number9
Publication statusPublished - 1991 Apr 1

ASJC Scopus subject areas

  • Organic Chemistry


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