Total synthesis of bafilomycin A1. 2. The assemblage and completion of the synthesis

Kazunobu Toshima, Hiroyuki Yamaguchi, Takaaki Jyojima, Yasunobu Noguchi, Masaya Nakata, Shuichi Matsumura

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

The total synthesis of the macrolide antibiotic, bafilomycin A1 (1), has been achieved by a convergent route involving aldol condensation between the 16-membered lactonic aldehyde 2 and the ethyl ketone 3, followed by desilylation.

Original languageEnglish
Pages (from-to)1073-1076
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number7
DOIs
Publication statusPublished - 1996 Feb 12

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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