Total synthesis of (+)-clavilactone A and (-)-clavilactone B by ring-opening/ring-closing metathesis

Ken Ichi Takao, Ryuki Nanamiya, Yuuki Fukushima, Ayumi Namba, Keisuke Yoshida, Kin Ichi Tadano

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


The enantioselective total synthesis of natural enantiomers of clavilactones A and B has been achieved. A key feature of the synthesis is the use of a ring-opening/ring-closing metathesis, which allows the one-pot transformation of a strained cyclobutenecarboxylate into a γ-butenolide.

Original languageEnglish
Pages (from-to)5582-5585
Number of pages4
JournalOrganic Letters
Issue number21
Publication statusPublished - 2013 Nov 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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