Total Synthesis of (+)-Hitachimycin

Amos B. Smith, Thomas A. Rano, Noritaka Chida, Gary A. Sulikowski

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


The first total synthesis of the macrocyclic antibiotic-antitumor agent (+)-hitachimycin (1) has been achieved via a convergent and efficient route (22 steps, 1.2% overall yield). The key transformation entailed a highly stereoselective, three-component coupling of (-)-5-methoxycyclopentenone (5) with a zincate derived from vinyl iodide 4a and aldehyde (-)-6.

Original languageEnglish
Pages (from-to)1136-1138
Number of pages3
JournalJournal of Organic Chemistry
Issue number4
Publication statusPublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry


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