Total synthesis of (+)-lactacystin from D-glucose

Noritaka Chida, Jun Takeoka, Noriko Tsutsumi, Seiichiro Ogawa

Research output: Contribution to journalArticlepeer-review

91 Citations (Scopus)


The chiral and stereoselective synthesis of (+)-lactacystin 1, the first non-protein neurotrophic factor, is described; the γ-lactam portion possessing a quaternary carbon in 1 was constructed stereoselectively from D-glucose using the allylic trichloroacetimidate rearrangement (Overman rearrangement) as the key reaction.

Original languageEnglish
Pages (from-to)793-794
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number7
Publication statusPublished - 1995 Dec 1

ASJC Scopus subject areas

  • Molecular Medicine


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