Total synthesis of merrilactone A

Masayuki Inoue, Takaaki Sato, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)


Merrilactone A (1) has been shown to possess neurotrophic activity and thus is expected to hold therapeutic potential in the treatment of neurodegeneration diseases. In this paper, we report the total synthesis of (±)-1, employing, as key steps, a novel desymmetrization protocol of meso-diketone to construct the core cis-bicyclo[3.3.0]octyl system of 1 (3 → 2) and a radical cyclization to install the highly congested C9-quaternary carbon (16 → 17).

Original languageEnglish
Pages (from-to)10772-10773
Number of pages2
JournalJournal of the American Chemical Society
Issue number36
Publication statusPublished - 2003 Sept 10
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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