Total synthesis of (-)-norzoanthamine

Daisuke Yamashita, Yoshihisa Murata, Naotsuka Hikage, Ken Ichi Takao, Atsuo Nakazaki, Susumu Kobayashi

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


No bones about it: (-)-Norzoanthamine, a promising candidate for an anti-osteoporotic drug, was the target of a total synthesis (see scheme). The final bisaminal formation with AcOH/H2O gave the DEFG ring, while the cyclization precursor was prepared by installing the remaining bisaminal unit after oxidative cleavage of the cyclopentanol moiety.

Original languageEnglish
Pages (from-to)1404-1406
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number8
Publication statusPublished - 2009 Feb 9
Externally publishedYes


  • Alkaloids
  • Cleavage reactions
  • Horner-emmons reaction
  • Natural products
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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