Total synthesis of nucleoside antibiotics possessing novel N-glycoside structures

Noritaka Chida

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Construction of aryl and heteroaryl N-glycoside structures by way of the palladium-catalyzed Buchwald-Hartwig N-arylation of pyranosylamines with aryl and heteroaryl halide derivatives is described. This methodology was successfully applied to the total synthesis of nucleoside antibiotics, spicamycin and dapiramicin B, possessing novel heteroaryl N-glycosides. Kinetic and thermodynamic analyses of heteroaryl N-glycosides are also reported.

Original languageEnglish
Pages (from-to)1105-1115
Number of pages11
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Issue number11
Publication statusPublished - 2008 Nov
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry


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