Total Synthesis of Paecilomycin B

Kiyomi Ohba; Masaya Nakata

doi:10.1021/acs.orglett.5b00983

Total Synthesis of Paecilomycin B

Kiyomi Ohba, Masaya Nakata

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Starting from the glucose-derived δ-lactone and the functionalized aryl bromide, the first total synthesis of naturally occurring paecilomycin B was achieved via functionalized aryl-β-C-glycoside synthesis using 2,4,6-triisopropylphenyllithium under Barbier-type reaction conditions and ring-closing metathesis as the key steps.

Original language	English
Pages (from-to)	2890-2893
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	12
DOIs	https://doi.org/10.1021/acs.orglett.5b00983
Publication status	Published - 2015 Jun 19

ASJC Scopus subject areas

Organic Chemistry
Physical and Theoretical Chemistry
Biochemistry

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10.1021/acs.orglett.5b00983

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title = "Total Synthesis of Paecilomycin B",

abstract = "Starting from the glucose-derived δ-lactone and the functionalized aryl bromide, the first total synthesis of naturally occurring paecilomycin B was achieved via functionalized aryl-β-C-glycoside synthesis using 2,4,6-triisopropylphenyllithium under Barbier-type reaction conditions and ring-closing metathesis as the key steps.",

author = "Kiyomi Ohba and Masaya Nakata",

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PY - 2015/6/19

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AB - Starting from the glucose-derived δ-lactone and the functionalized aryl bromide, the first total synthesis of naturally occurring paecilomycin B was achieved via functionalized aryl-β-C-glycoside synthesis using 2,4,6-triisopropylphenyllithium under Barbier-type reaction conditions and ring-closing metathesis as the key steps.

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Total Synthesis of Paecilomycin B

Abstract

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