Total synthesis of (-)-samaderine Y from (S)-(+)-carvone

Tony K.M. Shing, Ying Y. Yeung

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


(Chemical Equation Presented) Elegant, efficient, and enantiospecific describe the first total synthesis of the quassinoid (-)-samaderine Y (see scheme), which has been shown to display in vitro cytotoxicity and is of interest as a potential antitumor agent. Its synthesis has been accomplished from (S)-(+)-carvone in 21 steps.

Original languageEnglish
Pages (from-to)7981-7984
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number48
Publication statusPublished - 2005 Dec 9
Externally publishedYes


  • Antitumor agents
  • Fused-ring systems
  • Natural products
  • Quassinoids
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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