TY - JOUR
T1 - Total Synthesis of Skipped Diene Natural Products
AU - Sato, Takaaki
AU - Suto, Takahiro
AU - Nagashima, Yoshiyuki
AU - Mukai, Shori
AU - Chida, Noritaka
N1 - Funding Information:
This research was supported by the Otsuka Pharmaceutical Co. Award in Synthetic Organic Chemistry, Japan, and a JSPS fellowship to T. Suto (18 J11234).
Funding Information:
. Takahiro Suto received his B.Sc. degree in 2014 from Keio University, and his Ph.D. degree in 2019 from Keio University under the direction of Professors Noritaka Chida and Takaaki Sato. He received a JSPS fellowship from 2018 to 2019. He was awarded CSJ Student Presentation Award 2017. Currently, he works at SHIONOGI & CO., LTD
Publisher Copyright:
© 2021 Wiley-VCH GmbH
PY - 2021/10
Y1 - 2021/10
N2 - Skipped dienes (1,4-dienes) are widely distributed in a variety of biologically active natural products. The synthesis of these skipped dienes is a relatively undeveloped area compared with that of conjugated dienes (1,3-dienes) due to the sp3-hybridized carbon between two olefins. Especially, development of methods to meet both high stereoselectivity and convergency is highly challenging. This review focuses on recent advances in the synthesis of skipped dienes in the total synthesis of complex natural products, which are classified into three classes; a) skipped dienes comprised of two disubstituted olefins, b) skipped dienes including trisubstituted olefin(s), and c) 3-methyl skipped dienes.
AB - Skipped dienes (1,4-dienes) are widely distributed in a variety of biologically active natural products. The synthesis of these skipped dienes is a relatively undeveloped area compared with that of conjugated dienes (1,3-dienes) due to the sp3-hybridized carbon between two olefins. Especially, development of methods to meet both high stereoselectivity and convergency is highly challenging. This review focuses on recent advances in the synthesis of skipped dienes in the total synthesis of complex natural products, which are classified into three classes; a) skipped dienes comprised of two disubstituted olefins, b) skipped dienes including trisubstituted olefin(s), and c) 3-methyl skipped dienes.
KW - natural product
KW - olefination
KW - skipped diene
KW - stereoselectivity
KW - total synthesis
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U2 - 10.1002/ajoc.202100421
DO - 10.1002/ajoc.202100421
M3 - Review article
AN - SCOPUS:85113868063
SN - 2193-5807
VL - 10
SP - 2486
EP - 2502
JO - Asian Journal of Organic Chemistry
JF - Asian Journal of Organic Chemistry
IS - 10
ER -