Total synthesis of (+)-spiculoic acid A

Daisuke Matsumura, Takumi Toda, Takashi Hayamizu, Kiyoto Sawamura, Ken ichi Takao, Kin ichi Tadano

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The total synthesis of natural (+)-spiculoic acid A, a new cytotoxic marine natural product of polyketide origin, has been accomplished for the first time. The key step of the total synthesis was a stereoselective and high-yielding intramolecular Diels-Alder reaction of a highly functionalized (E,E,E)-2,7,9-dodecanal derivative for the construction of the core tetrahydroindan-2-one skeleton.

Original languageEnglish
Pages (from-to)3356-3358
Number of pages3
JournalTetrahedron Letters
Issue number26
Publication statusPublished - 2009 Jul 1


  • (+)-Spiculoic acid A
  • Cytotoxicity
  • Intramolecular Diels-Alder reaction
  • Marine natural product
  • Suzuki-Miyaura coupling
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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