Total synthesis of structurally unique γ-Lactam natural products

Ken Ichi Takao, Shin Ya Aoki, Kin Ichi Tadano

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Over the past three decades, a variety of highly functionalized /-lactam or spiro-heterocyclic γ-lactam natural products have been isolated. These compounds have attracted considerable attention due to their structural uniqueness as well as interesting biological activities. Thus, numerous synthetic organic chemists have established new methodologies for access to the y-lactam-type compounds. In this review, we summarize completed total syntheses of natural products containing a γ-lactam structure, such as ( - )-PI-091, (+)-epolactaene, lucilactaene, ( - )-pramanicin, ( - )-pseurotin A, ( - )-pseurotin F2, (+)-synerazol, and ( - )-azaspirene.

Original languageEnglish
Pages (from-to)460-469
Number of pages10
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Issue number5
Publication statusPublished - 2007 May
Externally publishedYes


  • Asymmetric synthesis
  • Bioactivities
  • Natural product synthesis
  • Spiro-heterocycles
  • Stereoselective synthesis
  • Total synthesis
  • γ-lactam

ASJC Scopus subject areas

  • Organic Chemistry


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