Total synthesis of structurally unique γ-Lactam natural products

Ken Ichi Takao; Shin Ya Aoki; Kin Ichi Tadano

doi:10.5059/yukigoseikyokaishi.65.460

Total synthesis of structurally unique γ-Lactam natural products

Ken Ichi Takao, Shin Ya Aoki, Kin Ichi Tadano

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Over the past three decades, a variety of highly functionalized /-lactam or spiro-heterocyclic γ-lactam natural products have been isolated. These compounds have attracted considerable attention due to their structural uniqueness as well as interesting biological activities. Thus, numerous synthetic organic chemists have established new methodologies for access to the y-lactam-type compounds. In this review, we summarize completed total syntheses of natural products containing a γ-lactam structure, such as ( - )-PI-091, (+)-epolactaene, lucilactaene, ( - )-pramanicin, ( - )-pseurotin A, ( - )-pseurotin F₂, (+)-synerazol, and ( - )-azaspirene.

Original language	English
Pages (from-to)	460-469
Number of pages	10
Journal	Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume	65
Issue number	5
DOIs	https://doi.org/10.5059/yukigoseikyokaishi.65.460
Publication status	Published - 2007 May
Externally published	Yes

Keywords

Asymmetric synthesis
Bioactivities
Natural product synthesis
Spiro-heterocycles
Stereoselective synthesis
Total synthesis
γ-lactam

ASJC Scopus subject areas

Organic Chemistry

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Cite this

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abstract = "Over the past three decades, a variety of highly functionalized /-lactam or spiro-heterocyclic γ-lactam natural products have been isolated. These compounds have attracted considerable attention due to their structural uniqueness as well as interesting biological activities. Thus, numerous synthetic organic chemists have established new methodologies for access to the y-lactam-type compounds. In this review, we summarize completed total syntheses of natural products containing a γ-lactam structure, such as ( - )-PI-091, (+)-epolactaene, lucilactaene, ( - )-pramanicin, ( - )-pseurotin A, ( - )-pseurotin F2, (+)-synerazol, and ( - )-azaspirene.",

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AU - Aoki, Shin Ya

AU - Tadano, Kin Ichi

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KW - Stereoselective synthesis

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Total synthesis of structurally unique γ-Lactam natural products

Abstract

Keywords

ASJC Scopus subject areas

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