Transcranial magnetic stimulation modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions in medicated patients with treatment-resistant depression

Shinsuke Kito; Takashi Hasegawa; Akihiro Takamiya; Takamasa Noda; Kazuyuki Nakagome; Teruhiko Higuchi; Yoshihiko Koga

doi:10.1176/appi.neuropsych.15120419

Transcranial magnetic stimulation modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions in medicated patients with treatment-resistant depression

Shinsuke Kito, Takashi Hasegawa, Akihiro Takamiya, Takamasa Noda, Kazuyuki Nakagome, Teruhiko Higuchi, Yoshihiko Koga

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

High-frequency left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been shown to have efficacy in treatment-resistant depression. However, the effects of rTMS on functional connectivity are still not clear. To examine changes in functional connectivity before and after rTMS, resting EEG of 14 patients with treatment-resistant depression was recorded twice at baseline and at week 4, respectively. The EEG data were analyzed using the standardized low-resolution brain electromagnetic tomography (sLORETA). The results reveal that high-frequency left prefrontal rTMS modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions, including the subgenual cingulate cortex and parahippocampal gyrus.

Original language	English
Pages (from-to)	155-159
Number of pages	5
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	29
Issue number	2
DOIs	https://doi.org/10.1176/appi.neuropsych.15120419
Publication status	Published - 2017 Mar 1
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1176/appi.neuropsych.15120419

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Kito, S., Hasegawa, T., Takamiya, A., Noda, T., Nakagome, K., Higuchi, T., & Koga, Y. (2017). Transcranial magnetic stimulation modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions in medicated patients with treatment-resistant depression. Journal of Neuropsychiatry and Clinical Neurosciences, 29(2), 155-159. https://doi.org/10.1176/appi.neuropsych.15120419

Transcranial magnetic stimulation modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions in medicated patients with treatment-resistant depression. / Kito, Shinsuke; Hasegawa, Takashi; Takamiya, Akihiro et al.
In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 29, No. 2, 01.03.2017, p. 155-159.

Research output: Contribution to journal › Article › peer-review

Kito, S, Hasegawa, T, Takamiya, A, Noda, T, Nakagome, K, Higuchi, T & Koga, Y 2017, 'Transcranial magnetic stimulation modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions in medicated patients with treatment-resistant depression', Journal of Neuropsychiatry and Clinical Neurosciences, vol. 29, no. 2, pp. 155-159. https://doi.org/10.1176/appi.neuropsych.15120419

Kito S, Hasegawa T, Takamiya A, Noda T, Nakagome K, Higuchi T et al. Transcranial magnetic stimulation modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions in medicated patients with treatment-resistant depression. Journal of Neuropsychiatry and Clinical Neurosciences. 2017 Mar 1;29(2):155-159. doi: 10.1176/appi.neuropsych.15120419

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abstract = "High-frequency left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been shown to have efficacy in treatment-resistant depression. However, the effects of rTMS on functional connectivity are still not clear. To examine changes in functional connectivity before and after rTMS, resting EEG of 14 patients with treatment-resistant depression was recorded twice at baseline and at week 4, respectively. The EEG data were analyzed using the standardized low-resolution brain electromagnetic tomography (sLORETA). The results reveal that high-frequency left prefrontal rTMS modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions, including the subgenual cingulate cortex and parahippocampal gyrus.",

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Transcranial magnetic stimulation modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions in medicated patients with treatment-resistant depression

Abstract

ASJC Scopus subject areas

UN SDGs

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