Transforming growth factor β2 level is elevated in neurons of Alzheimer's disease brains

Atsushi Noguchi; Mikiro Nawa; Sadakazu Aiso; Koichi Okamoto; Masaaki Matsuoka

doi:10.3109/00207450903139689

Transforming growth factor β2 level is elevated in neurons of Alzheimer's disease brains

Atsushi Noguchi, Mikiro Nawa, Sadakazu Aiso, Koichi Okamoto, Masaaki Matsuoka

Department of Anatomy

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Our earlier studies in vitro indicated that expression of TGFβ2 was induced by toxic amyloid βs (Aβs) in both glial and neuronal cells and increased levels of TGFβ2 triggered a neuronal cell death pathway related to Alzheimer's disease (AD) by binding to the extracellular domain of amyloid β precursor protein (APP). In this study we have demonstrated by immunohistochemical analysis that the levels of TGFβ2 are elevated in cells mainly consisting of neurons of both the hippocampi and cerebral cortices of human AD brains. This result indicates that upregulation of the TGFβ2 level is a common pathological feature of AD brains and suggests that it may be closely linked to the development of neuronal death related to AD.

Original language	English
Pages (from-to)	168-175
Number of pages	8
Journal	International Journal of Neuroscience
Volume	120
Issue number	3
DOIs	https://doi.org/10.3109/00207450903139689
Publication status	Published - 2010 Apr

Keywords

Alzheimer's disease
Neuronal death
TGFβ2

ASJC Scopus subject areas

Neuroscience(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/00207450903139689

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title = "Transforming growth factor β2 level is elevated in neurons of Alzheimer's disease brains",

abstract = "Our earlier studies in vitro indicated that expression of TGFβ2 was induced by toxic amyloid βs (Aβs) in both glial and neuronal cells and increased levels of TGFβ2 triggered a neuronal cell death pathway related to Alzheimer's disease (AD) by binding to the extracellular domain of amyloid β precursor protein (APP). In this study we have demonstrated by immunohistochemical analysis that the levels of TGFβ2 are elevated in cells mainly consisting of neurons of both the hippocampi and cerebral cortices of human AD brains. This result indicates that upregulation of the TGFβ2 level is a common pathological feature of AD brains and suggests that it may be closely linked to the development of neuronal death related to AD.",

keywords = "Alzheimer's disease, Neuronal death, TGFβ2",

author = "Atsushi Noguchi and Mikiro Nawa and Sadakazu Aiso and Koichi Okamoto and Masaaki Matsuoka",

note = "Funding Information: We are indebted to Dr. Ikuo Nishimoto for all of this research. We especially thank Ms. Takako Hiraki for essential assistance. This work was supported in part by grants from the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO).",

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doi = "10.3109/00207450903139689",

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T1 - Transforming growth factor β2 level is elevated in neurons of Alzheimer's disease brains

AU - Noguchi, Atsushi

AU - Nawa, Mikiro

AU - Aiso, Sadakazu

AU - Okamoto, Koichi

AU - Matsuoka, Masaaki

N1 - Funding Information: We are indebted to Dr. Ikuo Nishimoto for all of this research. We especially thank Ms. Takako Hiraki for essential assistance. This work was supported in part by grants from the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO).

PY - 2010/4

Y1 - 2010/4

N2 - Our earlier studies in vitro indicated that expression of TGFβ2 was induced by toxic amyloid βs (Aβs) in both glial and neuronal cells and increased levels of TGFβ2 triggered a neuronal cell death pathway related to Alzheimer's disease (AD) by binding to the extracellular domain of amyloid β precursor protein (APP). In this study we have demonstrated by immunohistochemical analysis that the levels of TGFβ2 are elevated in cells mainly consisting of neurons of both the hippocampi and cerebral cortices of human AD brains. This result indicates that upregulation of the TGFβ2 level is a common pathological feature of AD brains and suggests that it may be closely linked to the development of neuronal death related to AD.

AB - Our earlier studies in vitro indicated that expression of TGFβ2 was induced by toxic amyloid βs (Aβs) in both glial and neuronal cells and increased levels of TGFβ2 triggered a neuronal cell death pathway related to Alzheimer's disease (AD) by binding to the extracellular domain of amyloid β precursor protein (APP). In this study we have demonstrated by immunohistochemical analysis that the levels of TGFβ2 are elevated in cells mainly consisting of neurons of both the hippocampi and cerebral cortices of human AD brains. This result indicates that upregulation of the TGFβ2 level is a common pathological feature of AD brains and suggests that it may be closely linked to the development of neuronal death related to AD.

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KW - Neuronal death

KW - TGFβ2

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Transforming growth factor β2 level is elevated in neurons of Alzheimer's disease brains

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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