TY - JOUR
T1 - Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells
AU - Yamaoka, Takashi
AU - Matsui, Takefumi
AU - Yamaguchi, Takashi
AU - Moritani, Maki
AU - Itakura, Mitsuo
AU - Yoshino, Kenji
AU - Yano, Makiko
AU - Yamada, Taketo
AU - Hata, Jun ichi
AU - Noji, Sumihare
PY - 2002
Y1 - 2002
N2 - FGF signaling is essential for normal development of pancreatic islets. To examine the effects of overexpressed FGF8 and FGF10 on pancreatic development, we generated FGF8- and FGF10-transgenic mice (Tg mice) under the control of the glucagon promoter. In FGF8-Tg mice, hepatocyte-like cells were observed in the periphery of pancreatic islets, but areas of α and β cells did not decrease, whereas in FGF10-Tg mice, pancreatic ductal and acinar cells were found in islets, concomitantly with disturbed β-cell differentiation. These results suggest that FGF8 and FGF10 play important roles in development of hepatocytes and exocrine cells, respectively, and explain the absence of FGF8 expression in normal islets and pancreatic hypoplasia in FGF10-deficient mice.
AB - FGF signaling is essential for normal development of pancreatic islets. To examine the effects of overexpressed FGF8 and FGF10 on pancreatic development, we generated FGF8- and FGF10-transgenic mice (Tg mice) under the control of the glucagon promoter. In FGF8-Tg mice, hepatocyte-like cells were observed in the periphery of pancreatic islets, but areas of α and β cells did not decrease, whereas in FGF10-Tg mice, pancreatic ductal and acinar cells were found in islets, concomitantly with disturbed β-cell differentiation. These results suggest that FGF8 and FGF10 play important roles in development of hepatocytes and exocrine cells, respectively, and explain the absence of FGF8 expression in normal islets and pancreatic hypoplasia in FGF10-deficient mice.
KW - Anophthalmia
KW - Fibroblast growth factor 10
KW - Fibroblast growth factor 8
KW - Glucagon promoter
KW - Hepatocyte
KW - Pancreatic islet
KW - Thyroid cancer
KW - Transdifferentiation
KW - Transgenic mice
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U2 - 10.1006/bbrc.2002.6601
DO - 10.1006/bbrc.2002.6601
M3 - Article
C2 - 11890684
AN - SCOPUS:0036298951
SN - 0006-291X
VL - 292
SP - 138
EP - 143
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -
