Translocation of bacteria from the gastrointestinal tract in immunodef icient mice

T. Ohsugi, Y. Kiuchi, K. Shimoda, S. Oguri, K. Maejima

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Host defence mechanisms associated with the inhibition of translocation of bacteria from the gastrointestinal (GI) tract were investigated in SCID and beige mice after decontamination with oral antibiotics and colonization with Escherichia coli C25. SCID mice, which have impaired T and B cell function, tended to have a greater incidence of bacterial translocation from the GI tract up to 7 days after inoculation compared with controls. However, after 7 days both SCID and controls cleared the E. coli C25 from the liver, spleen, blood and peritoneal cavity. Beige mice, with impaired NK cell and polymorphonuclear leukocyte function, were not able to clear the inoculated bacteria from their liver by 14 days after inoculation although the controls were cleared by 7 days. Numbers of bacteria in the mesenteric lymph nodes (MLN) of beige mice did not decrease significantly by 14 days after inoculation, whereas numbers in SCID mice decreased markedly within 7 days. These results suggest that defence mechanisms other than T and B cell function are important in the inhibition of systemic infection from the GI tract.

Original languageEnglish
Pages (from-to)46-50
Number of pages5
JournalLaboratory Animals
Issue number1
Publication statusPublished - 1996
Externally publishedYes


  • Bacterial translocation
  • Beige mice
  • Gastrointestinal tract
  • SCID mice

ASJC Scopus subject areas

  • Animal Science and Zoology
  • General Veterinary


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