Transmyocardial revascularization aggravates myocardial ischemia around the channels in the immediate phase

Naoichiro Hattan, Kazunobu Ban, Etsuro Tanaka, Sumihisa Abe, Takafumi Sekka, Yoshinori Sugio, Minhaz U. Mohammed, Eriko Sato, Yoshiro Shinozai, Yozo Onishi, Hisayoshi Suma, Shunnosuke Handa, Shiaki Kawada, Shingo Hori, Atsuo Iida, Hiroe Nakazawa, Hidezo Mori

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


We examined whether transmyocardial revascularization (TMR) relieves myocardial ischemia by increasing regional perfusion via the transmural channels in acute canine experiments. Regional blood flow during tram sient coronary ligation (2 min) was compared before and 30 min after TMR, and at the third transient ischemia the mid-left ventricle (LV) was cut and immediately frozen along the short axis for the analysis of NADH fluorescence in the regions around the TMR channels. In low-resolution analysis (2-4 g tissue or 2-3 cm2 area), regional perfusion was not significantly altered after TMR, and NADH fluorescence was observed throughout the ischemic region without significant spatial variation. High-resolution analysis (2.8 mg, 1 mm x 1 mm) revealed that the flow after TMR was lower, and NADH fluorescence was higher in the regions close to the channels (1-2 mm) than in the regions 3-4 mm away from them. Creating TMR channels did not improve the regional perfusion and rather aggravated the local ischemia in the vicinity of the channels in the immediate phase.

Original languageEnglish
Pages (from-to)H1392-H1396
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number3 48-3
Publication statusPublished - 2000
Externally publishedYes


  • Microspheres
  • NADH fluorescence
  • Regional blood flow

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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