Transmyocardial revascularization aggravates myocardial ischemia around the channels in the immediate phase

Naoichiro Hattan; Kazunobu Ban; Etsuro Tanaka; Sumihisa Abe; Takafumi Sekka; Yoshinori Sugio; Minhaz U. Mohammed; Eriko Sato; Yoshiro Shinozai; Yozo Onishi; Hisayoshi Suma; Shunnosuke Handa; Shiaki Kawada; Shingo Hori; Atsuo Iida; Hiroe Nakazawa; Hidezo Mori

doi:10.1152/ajpheart.2000.279.3.h1392

Transmyocardial revascularization aggravates myocardial ischemia around the channels in the immediate phase

Naoichiro Hattan, Kazunobu Ban, Etsuro Tanaka, Sumihisa Abe, Takafumi Sekka, Yoshinori Sugio, Minhaz U. Mohammed, Eriko Sato, Yoshiro Shinozai, Yozo Onishi, Hisayoshi Suma, Shunnosuke Handa, Shiaki Kawada, Shingo Hori, Atsuo Iida, Hiroe Nakazawa, Hidezo Mori

Research output: Contribution to journal › Article › peer-review

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Abstract

We examined whether transmyocardial revascularization (TMR) relieves myocardial ischemia by increasing regional perfusion via the transmural channels in acute canine experiments. Regional blood flow during tram sient coronary ligation (2 min) was compared before and 30 min after TMR, and at the third transient ischemia the mid-left ventricle (LV) was cut and immediately frozen along the short axis for the analysis of NADH fluorescence in the regions around the TMR channels. In low-resolution analysis (2-4 g tissue or 2-3 cm² area), regional perfusion was not significantly altered after TMR, and NADH fluorescence was observed throughout the ischemic region without significant spatial variation. High-resolution analysis (2.8 mg, 1 mm x 1 mm) revealed that the flow after TMR was lower, and NADH fluorescence was higher in the regions close to the channels (1-2 mm) than in the regions 3-4 mm away from them. Creating TMR channels did not improve the regional perfusion and rather aggravated the local ischemia in the vicinity of the channels in the immediate phase.

Original language	English
Pages (from-to)	H1392-H1396
Journal	American Journal of Physiology - Heart and Circulatory Physiology
Volume	279
Issue number	3 48-3
DOIs	https://doi.org/10.1152/ajpheart.2000.279.3.h1392
Publication status	Published - 2000
Externally published	Yes

Keywords

Microspheres
NADH fluorescence
Regional blood flow

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1152/ajpheart.2000.279.3.h1392

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Hattan, N., Ban, K., Tanaka, E., Abe, S., Sekka, T., Sugio, Y., Mohammed, M. U., Sato, E., Shinozai, Y., Onishi, Y., Suma, H., Handa, S., Kawada, S., Hori, S., Iida, A., Nakazawa, H., & Mori, H. (2000). Transmyocardial revascularization aggravates myocardial ischemia around the channels in the immediate phase. American Journal of Physiology - Heart and Circulatory Physiology, 279(3 48-3), H1392-H1396. https://doi.org/10.1152/ajpheart.2000.279.3.h1392

Hattan, N, Ban, K, Tanaka, E, Abe, S, Sekka, T, Sugio, Y, Mohammed, MU, Sato, E, Shinozai, Y, Onishi, Y, Suma, H, Handa, S, Kawada, S, Hori, S, Iida, A, Nakazawa, H & Mori, H 2000, 'Transmyocardial revascularization aggravates myocardial ischemia around the channels in the immediate phase', American Journal of Physiology - Heart and Circulatory Physiology, vol. 279, no. 3 48-3, pp. H1392-H1396. https://doi.org/10.1152/ajpheart.2000.279.3.h1392

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abstract = "We examined whether transmyocardial revascularization (TMR) relieves myocardial ischemia by increasing regional perfusion via the transmural channels in acute canine experiments. Regional blood flow during tram sient coronary ligation (2 min) was compared before and 30 min after TMR, and at the third transient ischemia the mid-left ventricle (LV) was cut and immediately frozen along the short axis for the analysis of NADH fluorescence in the regions around the TMR channels. In low-resolution analysis (2-4 g tissue or 2-3 cm2 area), regional perfusion was not significantly altered after TMR, and NADH fluorescence was observed throughout the ischemic region without significant spatial variation. High-resolution analysis (2.8 mg, 1 mm x 1 mm) revealed that the flow after TMR was lower, and NADH fluorescence was higher in the regions close to the channels (1-2 mm) than in the regions 3-4 mm away from them. Creating TMR channels did not improve the regional perfusion and rather aggravated the local ischemia in the vicinity of the channels in the immediate phase.",

keywords = "Microspheres, NADH fluorescence, Regional blood flow",

author = "Naoichiro Hattan and Kazunobu Ban and Etsuro Tanaka and Sumihisa Abe and Takafumi Sekka and Yoshinori Sugio and Mohammed, {Minhaz U.} and Eriko Sato and Yoshiro Shinozai and Yozo Onishi and Hisayoshi Suma and Shunnosuke Handa and Shiaki Kawada and Shingo Hori and Atsuo Iida and Hiroe Nakazawa and Hidezo Mori",

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doi = "10.1152/ajpheart.2000.279.3.h1392",

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T1 - Transmyocardial revascularization aggravates myocardial ischemia around the channels in the immediate phase

AU - Hattan, Naoichiro

AU - Ban, Kazunobu

AU - Tanaka, Etsuro

AU - Abe, Sumihisa

AU - Sekka, Takafumi

AU - Sugio, Yoshinori

AU - Mohammed, Minhaz U.

AU - Sato, Eriko

AU - Shinozai, Yoshiro

AU - Onishi, Yozo

AU - Suma, Hisayoshi

AU - Handa, Shunnosuke

AU - Kawada, Shiaki

AU - Hori, Shingo

AU - Iida, Atsuo

AU - Nakazawa, Hiroe

AU - Mori, Hidezo

PY - 2000

Y1 - 2000

N2 - We examined whether transmyocardial revascularization (TMR) relieves myocardial ischemia by increasing regional perfusion via the transmural channels in acute canine experiments. Regional blood flow during tram sient coronary ligation (2 min) was compared before and 30 min after TMR, and at the third transient ischemia the mid-left ventricle (LV) was cut and immediately frozen along the short axis for the analysis of NADH fluorescence in the regions around the TMR channels. In low-resolution analysis (2-4 g tissue or 2-3 cm2 area), regional perfusion was not significantly altered after TMR, and NADH fluorescence was observed throughout the ischemic region without significant spatial variation. High-resolution analysis (2.8 mg, 1 mm x 1 mm) revealed that the flow after TMR was lower, and NADH fluorescence was higher in the regions close to the channels (1-2 mm) than in the regions 3-4 mm away from them. Creating TMR channels did not improve the regional perfusion and rather aggravated the local ischemia in the vicinity of the channels in the immediate phase.

AB - We examined whether transmyocardial revascularization (TMR) relieves myocardial ischemia by increasing regional perfusion via the transmural channels in acute canine experiments. Regional blood flow during tram sient coronary ligation (2 min) was compared before and 30 min after TMR, and at the third transient ischemia the mid-left ventricle (LV) was cut and immediately frozen along the short axis for the analysis of NADH fluorescence in the regions around the TMR channels. In low-resolution analysis (2-4 g tissue or 2-3 cm2 area), regional perfusion was not significantly altered after TMR, and NADH fluorescence was observed throughout the ischemic region without significant spatial variation. High-resolution analysis (2.8 mg, 1 mm x 1 mm) revealed that the flow after TMR was lower, and NADH fluorescence was higher in the regions close to the channels (1-2 mm) than in the regions 3-4 mm away from them. Creating TMR channels did not improve the regional perfusion and rather aggravated the local ischemia in the vicinity of the channels in the immediate phase.

KW - Microspheres

KW - NADH fluorescence

KW - Regional blood flow

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Transmyocardial revascularization aggravates myocardial ischemia around the channels in the immediate phase

Abstract

Keywords

ASJC Scopus subject areas

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