Transplantability and Sensitivity to Natural Killer Cells of Aclarubicin-resistant Murine Lymphoma

Yoshikazu Sugimoto; Yoko Hirakawa; Nobuyuki Tanaka; Makoto Tahara; Isao Sato; Toshio Nishimura; Hideo Suzuki; Nobuo Tanaka

Transplantability and Sensitivity to Natural Killer Cells of Aclarubicin-resistant Murine Lymphoma

Yoshikazu Sugimoto, Yoko Hirakawa, Nobuyuki Tanaka, Makoto Tahara, Isao Sato, Toshio Nishimura, Hideo Suzuki, Nobuo Tanaka

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

DBA/2 mice implanted i.p. with an aclarubicin (ACR)–resistant subline of L5178Y cells survived 4- to 5-fold longer than those with the parental cells; and animals with the Adriamycin- or bleomycin–resistant subline displayed an intermediate survival period. The i.p. treatment of mice with cyclophosphamide markedly enhanced i.p. growth of the ACR–resistant cells, suggesting that A certain host defense mechanism participates in the lower transplantability. In vitro, the ACR–resistant subline showed much higher sensitivity to natural killer cells. The i.p. pretreatment with anti-asialo-GM1 antibody markedly reduced the mean survival period of mice implanted i.p. with the ACR–resistant cells, suggesting that natural killer cells play an important role in the defense against transplantation of the ACR–resistant cells. copyright.

Original language	English
Pages (from-to)	5646-5648
Number of pages	3
Journal	Cancer Research
Volume	46
Issue number	11
Publication status	Published - 1986 Nov 1
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Transplantability and Sensitivity to Natural Killer Cells of Aclarubicin-resistant Murine Lymphoma",

abstract = "DBA/2 mice implanted i.p. with an aclarubicin (ACR)–resistant subline of L5178Y cells survived 4- to 5-fold longer than those with the parental cells; and animals with the Adriamycin- or bleomycin–resistant subline displayed an intermediate survival period. The i.p. treatment of mice with cyclophosphamide markedly enhanced i.p. growth of the ACR–resistant cells, suggesting that A certain host defense mechanism participates in the lower transplantability. In vitro, the ACR–resistant subline showed much higher sensitivity to natural killer cells. The i.p. pretreatment with anti-asialo-GM1 antibody markedly reduced the mean survival period of mice implanted i.p. with the ACR–resistant cells, suggesting that natural killer cells play an important role in the defense against transplantation of the ACR–resistant cells. copyright.",

author = "Yoshikazu Sugimoto and Yoko Hirakawa and Nobuyuki Tanaka and Makoto Tahara and Isao Sato and Toshio Nishimura and Hideo Suzuki and Nobuo Tanaka",

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T1 - Transplantability and Sensitivity to Natural Killer Cells of Aclarubicin-resistant Murine Lymphoma

AU - Sugimoto, Yoshikazu

AU - Hirakawa, Yoko

AU - Tanaka, Nobuyuki

AU - Tahara, Makoto

AU - Sato, Isao

AU - Nishimura, Toshio

AU - Suzuki, Hideo

AU - Tanaka, Nobuo

PY - 1986/11/1

Y1 - 1986/11/1

N2 - DBA/2 mice implanted i.p. with an aclarubicin (ACR)–resistant subline of L5178Y cells survived 4- to 5-fold longer than those with the parental cells; and animals with the Adriamycin- or bleomycin–resistant subline displayed an intermediate survival period. The i.p. treatment of mice with cyclophosphamide markedly enhanced i.p. growth of the ACR–resistant cells, suggesting that A certain host defense mechanism participates in the lower transplantability. In vitro, the ACR–resistant subline showed much higher sensitivity to natural killer cells. The i.p. pretreatment with anti-asialo-GM1 antibody markedly reduced the mean survival period of mice implanted i.p. with the ACR–resistant cells, suggesting that natural killer cells play an important role in the defense against transplantation of the ACR–resistant cells. copyright.

AB - DBA/2 mice implanted i.p. with an aclarubicin (ACR)–resistant subline of L5178Y cells survived 4- to 5-fold longer than those with the parental cells; and animals with the Adriamycin- or bleomycin–resistant subline displayed an intermediate survival period. The i.p. treatment of mice with cyclophosphamide markedly enhanced i.p. growth of the ACR–resistant cells, suggesting that A certain host defense mechanism participates in the lower transplantability. In vitro, the ACR–resistant subline showed much higher sensitivity to natural killer cells. The i.p. pretreatment with anti-asialo-GM1 antibody markedly reduced the mean survival period of mice implanted i.p. with the ACR–resistant cells, suggesting that natural killer cells play an important role in the defense against transplantation of the ACR–resistant cells. copyright.

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Transplantability and Sensitivity to Natural Killer Cells of Aclarubicin-resistant Murine Lymphoma

Abstract

ASJC Scopus subject areas

UN SDGs

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