Transplantation of neural stem cells into epileptic brain

Yoshihito Matsumoto, Atsushi Sindo, Nobuyuki Kawai, Katsuzo Kunishio, Seigo Nagao, Tetsuji Miyazaki, Toshifumi Itano, Yohei Okada, Takuya Shimazaki, Hideyuki Okano

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Embryonic stem cells (ES cells) differentiate into multiple cell lineages including neurons and glia. Subsequent to the isolation of neural stem cells, they can be expanded, genetically modified and extensively characterized prior to transplantation. These neural stem cells represent an ideal cell type for transplantation purpose in the central nervous system due to their multipotency. In the present study, we optimized the effective method to induce the differentiation of GABAergic neurons from neurospheres that had been derived from ES cells. Moreover, the effect of the transplantation of these cells was investigated on morphological and functional outcome in grafted mice kindled by electrical stimulation.

Original languageEnglish
Pages (from-to)489-492
Number of pages4
JournalInternational Congress Series
Issue numberC
Publication statusPublished - 2003 Jun 1


  • ES cell
  • Epilepsy
  • GABA
  • Kindling
  • Transplantation

ASJC Scopus subject areas

  • General Medicine


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