Transplantation of neural stem cells into spinal cord after injury

Masaya Nakamura, Yoshiaki Toyama

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


Recovery from central nervous system damage in adult mammals is hindered by their limited ability to replace lost cells and damaged myelin, and reestablish functional neural connections. However, recent progresses in stem cell biology are making it feasible to induce the regeneration of injured axons after spinal cord injury. Transplantation of in vitro expanded neural stem cells into rat spinal cord 9 days after contusion injury induced their differentiation into neurons and oligodendrocytes, and the functional recovery of skilled forelimb movement. It was partly because the microenvironment within the injured spinal cord at 9 days after injury was more favorable for grafted neural stem cells in terms of their survival and differentiation.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number3
Publication statusPublished - 2003 Mar

ASJC Scopus subject areas

  • General Medicine


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